Abstract：
Pericytes are located in the stromal membrane of the capillary outer wall and contain endothelial cells (ECs). They are pivotal in regulating blood flow, enhancing vascular stability, and maintaining the integrity of the blood-retina barrier (BRB)/blood-brain barrier (BBB). The pluripotency of pericytes allows them to differentiate into various cell types, highlighting their significance in vascular disease pathogenesis, as demonstrated by previous studies. This potential enables pericytes to be a potential biomarker for the diagnosis and a target for treatment of vascular disorders. The retina, an essential part of the eyeball, is an extension of cerebral tissue with a transparent refractive medium. It offers a unique window for assessing systemic microvascular lesions. Routine fundus examination is necessary for patients with diabetes and hypertension. Manifestations, such as retinal artery tortuosity, dilation, stenosis, and abnormal arteriovenous anastomosis, serve as typical hallmarks of retinal vasculopathy. Therefore, studies of ocular vascular diseases significantly facilitate the exploration of systemic vascular diseases.
摘要：
周细胞位于毛细血管外壁的基质膜中，含有内皮细胞（EC）。它们在调节血液流动方面至关重要，增强血管稳定性，维持血-视网膜屏障(BRB)/血脑屏障(BBB)的完整性。周细胞的多能性使它们能够分化成各种细胞类型,强调它们在血管疾病发病机理中的重要性，正如以前的研究所证明的那样。这种潜力使周细胞成为诊断的潜在生物标志物和治疗血管疾病的靶标。视网膜,眼球的重要部分,是具有透明折射介质的脑组织的延伸。它为评估全身微血管病变提供了一个独特的窗口。糖尿病和高血压患者需要进行常规眼底检查。表现,比如视网膜动脉弯曲,膨胀,狭窄,和异常的动静脉吻合,作为视网膜血管病变的典型标志。因此,眼血管疾病的研究大大促进了系统性血管疾病的探索。
