Abstract：
Abstract Background: Photodynamic therapy (PDT) is a minimally invasive therapy that was gradually established as a first-line treatment for vascular abnormalities. Its action depends on the appropriate wavelength of light and photosensitizer to produce toxic oxygen species and cause cell death. Objective: Several new clinical improvements and trends in PDT have been described in recent years. The aim of this review is to provide an overview of the current data from clinical trials. Methods: In this review, we introduce and generalize the wavelength, duration, dose, strength, and photosensitizer of PDT for the treatment of vascular abnormalities, such as circumscribed choroidal hemangiomas (CCH), choroidal neovascularization (CNV) and capillary malformation (CM). Results: The systematic review findings indicate that the application of PDT is a safe effective method to treat CCH, CNV and CM. However, PDT also has early onset side effects and late onset side effects. Conclusions: Based on the discussion of the effectiveness of PDT, we conclude that PDT has great potential for clinical use, although PDT has possible side effects.
摘要：
摘要背景：光动力疗法（PDT）是一种微创疗法，逐渐被确立为血管异常的一线治疗方法。其作用取决于适当波长的光和光敏剂，以产生有毒的氧物种并引起细胞死亡。目的：近年来已经描述了PDT的一些新的临床改进和趋势。这篇综述的目的是概述临床试验的当前数据。方法：在这篇综述中，我们引入和推广波长，持续时间,剂量,力量,和PDT光敏剂用于治疗血管异常，例如外接脉络膜血管瘤（CCH），脉络膜新生血管（CNV）和毛细血管畸形（CM）。结果：系统评价结果表明，应用PDT是治疗CCH的安全有效方法，CNV和CM。然而,PDT还具有早发性副作用和晚发性副作用。结论：基于对PDT有效性的讨论，我们得出结论，PDT具有巨大的临床应用潜力，虽然PDT有可能的副作用。
