PDF(Pubmed)
Abstract：
BACKGROUND: Ulcerative colitis (UC) and systemic lupus erythematosus (SLE) are both systemic immunoreactive diseases, and their pathogenesis depends on the interaction between genes and environmental factors. There are no reports of UC with SLE in China, but six cases of SLE with UC have been reported in China. The combination of these two diseases has distinct effects on the pathogenesis of both diseases.
METHODS: A female patient (30 years old) came to our hospital due to dull umbilical pain, diarrhea and mucous bloody stool in August 2018 and was diagnosed with UC. The symptoms were relieved after oral administration of mesalazine (1 g po tid) or folic acid (5 mg po qd), and the patient were fed a control diet. On June 24, 2019, the patient was admitted for treatment due to anemia and tinnitus. During hospitalization, the patient had repeated low-grade fever and a progressively decreased Hb level. Blood tests revealed positive antinuclear antibody test, positive anti-dsDNA antibody, 0.24 g/L C3 (0.9-1.8 g/L), 0.04 g/L C4 (0.1-0.4 g/L), 32.37 g/L immunoglobulin (8-17 g/L), and 31568.1 mg/24 h total 24-h urine protein (0-150 mg/24 h). The patient was diagnosed with SLE involving the joints, kidneys and blood system. Previously reported cases of SLE were retrieved from PubMed to characterize clinicopathological features and identify prognostic factors for SLE.
CONCLUSIONS: The patient was discharged in remission after a series of treatments, such as intravenous methylprednisolone sodium succinate, intravenous human immunoglobulin, cyclophosphamide injection, and plasma exchange. After discharge, the patient took oral prednisone acetate tablets, cyclosporine capsules, hydroxychloroquine sulfate tablets and other treatments for symptoms and was followed up regularly for 1 month, after which the patient\'s condition continued to improve and stabilize.
METHODS: A female patient (30 years old) came to our hospital due to dull umbilical pain, diarrhea and mucous bloody stool in August 2018 and was diagnosed with UC. The symptoms were relieved after oral administration of mesalazine (1 g po tid) or folic acid (5 mg po qd), and the patient were fed a control diet. On June 24, 2019, the patient was admitted for treatment due to anemia and tinnitus. During hospitalization, the patient had repeated low-grade fever and a progressively decreased Hb level. Blood tests revealed positive antinuclear antibody test, positive anti-dsDNA antibody, 0.24 g/L C3 (0.9-1.8 g/L), 0.04 g/L C4 (0.1-0.4 g/L), 32.37 g/L immunoglobulin (8-17 g/L), and 31568.1 mg/24 h total 24-h urine protein (0-150 mg/24 h). The patient was diagnosed with SLE involving the joints, kidneys and blood system. Previously reported cases of SLE were retrieved from PubMed to characterize clinicopathological features and identify prognostic factors for SLE.
CONCLUSIONS: The patient was discharged in remission after a series of treatments, such as intravenous methylprednisolone sodium succinate, intravenous human immunoglobulin, cyclophosphamide injection, and plasma exchange. After discharge, the patient took oral prednisone acetate tablets, cyclosporine capsules, hydroxychloroquine sulfate tablets and other treatments for symptoms and was followed up regularly for 1 month, after which the patient\'s condition continued to improve and stabilize.
摘要：
背景：溃疡性结肠炎（UC）和系统性红斑狼疮（SLE）都是全身性免疫反应性疾病，其发病机制取决于基因和环境因素之间的相互作用。在中国没有UC合并SLE的报告，但中国已报告6例SLE合并UC。这两种疾病的组合对两种疾病的发病机理具有不同的影响。
方法：一名女性患者（30岁）因脐隐痛来到我院，2018年8月腹泻和粘液血便，诊断为UC。口服美沙拉嗪（1gpotid）或叶酸（5mgpoqd）后症状缓解，患者接受对照饮食。2019年6月24日，患者因贫血和耳鸣入院治疗。住院期间,患者反复出现低热和Hb水平逐渐降低.验血显示抗核抗体检测呈阳性,抗dsDNA抗体阳性，0.24g/LC3（0.9-1.8g/L），0.04克/升C4（0.1-0.4克/升），32.37g/L免疫球蛋白（8-17g/L），和31568.1毫克/24小时总24小时尿蛋白（0-150毫克/24小时）。患者被诊断为累及关节的SLE,肾脏和血液系统。以前报道的SLE病例从PubMed检索，以表征临床病理特征并确定SLE的预后因素。
结论：患者经过一系列治疗后缓解出院，如静脉注射甲基强的松龙琥珀酸钠，静脉注射人免疫球蛋白，环磷酰胺注射液,和血浆置换。放电后,患者口服醋酸泼尼松片，环孢素胶囊,硫酸羟氯喹片等治疗症状，并定期随访1个月，之后，患者的病情继续改善和稳定。
方法：一名女性患者（30岁）因脐隐痛来到我院，2018年8月腹泻和粘液血便，诊断为UC。口服美沙拉嗪（1gpotid）或叶酸（5mgpoqd）后症状缓解，患者接受对照饮食。2019年6月24日，患者因贫血和耳鸣入院治疗。住院期间,患者反复出现低热和Hb水平逐渐降低.验血显示抗核抗体检测呈阳性,抗dsDNA抗体阳性，0.24g/LC3（0.9-1.8g/L），0.04克/升C4（0.1-0.4克/升），32.37g/L免疫球蛋白（8-17g/L），和31568.1毫克/24小时总24小时尿蛋白（0-150毫克/24小时）。患者被诊断为累及关节的SLE,肾脏和血液系统。以前报道的SLE病例从PubMed检索，以表征临床病理特征并确定SLE的预后因素。
结论：患者经过一系列治疗后缓解出院，如静脉注射甲基强的松龙琥珀酸钠，静脉注射人免疫球蛋白，环磷酰胺注射液,和血浆置换。放电后,患者口服醋酸泼尼松片，环孢素胶囊,硫酸羟氯喹片等治疗症状，并定期随访1个月，之后，患者的病情继续改善和稳定。
