关键词: CBC Dogs Indices Lymphoma Ratios

Mesh : Dogs Animals Dog Diseases / blood diagnosis Retrospective Studies Case-Control Studies Male Female Blood Cell Count / veterinary Lymphoma, Large B-Cell, Diffuse / veterinary blood diagnosis mortality drug therapy Lymphoma, B-Cell / veterinary blood diagnosis Prognosis

来  源:   DOI:10.5455/OVJ.2024.v14.i4.5   PDF(Pubmed)

Abstract:
UNASSIGNED: Canine lymphoma is the most common hematopoietic cancer in dogs. Numerous studies have evaluated the prognostic value of hematological abnormalities and ratios in both humans and dogs with lymphoma.
UNASSIGNED: To compare hematological parameters and complete blood count ratios between a population of dogs affected by lymphoma and healthy dogs to identify potential prognostic markers for lymphoma.
UNASSIGNED: This retrospective case-control study compares hematological parameters and complete blood count ratios between a population of 114 dogs affected by multicentric large B-cell lymphoma (LBCL) and 60 healthy dogs.
UNASSIGNED: The study found several statistically significant differences between the hematological indices of LBCL dogs and healthy dogs, but no correlation between these parameters and the survival times of 78 dogs treated with chemotherapy Madison Wisconsin protocol. In addition, hematological alterations were evaluated such as anemia, leukocytosis, and thrombocytopenia.
UNASSIGNED: Hematological ratios have been suggested as potential prognostic markers for canine LBCL but their real prognostic value remains controversial and requires future investigation.
摘要:
犬淋巴瘤是狗中最常见的造血系统癌症。许多研究已经评估了血液学异常和比率在患有淋巴瘤的人和狗中的预后价值。
比较受淋巴瘤影响的狗群体与健康狗之间的血液学参数和全血细胞计数比率,以确定淋巴瘤的潜在预后标志物。
这项回顾性病例对照研究比较了受多中心大B细胞淋巴瘤(LBCL)影响的114只狗和60只健康狗之间的血液学参数和全血细胞计数比。
该研究发现LBCL犬和健康犬的血液学指标之间存在一些统计学上的显着差异,但是这些参数与接受麦迪逊威斯康星化疗方案治疗的78只狗的生存时间之间没有相关性。此外,血液学改变进行评估,如贫血,白细胞增多,和血小板减少症.
血液学比值已被认为是犬LBCL的潜在预后标志物,但其真正的预后价值仍存在争议,需要进一步研究。
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