PDF(Pubmed)
Abstract：
Sarcopenia, a complex muscular condition driven by multi-systemic dysregulation and its interactions with lifestyle, physical attributes, and mental health, lacks effective drug treatments, relying primarily on non-pharmacological interventions. Fragmented approaches may prove suboptimal due to its complexity, underscoring the potential for multidomain interventions-a combination of two or more strategies to improve individual health-as a promising treatment option. This review examines the possible roles of multidomain interventions in sarcopenia, specifically addressing their effects on muscle mass and quality, muscle strength, and physical performance in older adults. While the updated literature highlights the beneficial consequences of multidomain interventions in enhancing physical performance outcomes, gaps persist in understanding their influence on the biological aspects of sarcopenia. Promising initial findings suggest changes in plasma inflammatory markers or muscle turnover networks, but further research is necessary to clarify the disease-modifying effects of multidomain intervention in sarcopenic patients.
摘要：
肌肉减少症,由多系统失调及其与生活方式的相互作用驱动的复杂肌肉状况，物理属性，和心理健康，缺乏有效的药物治疗,主要依靠非药物干预。由于其复杂性，碎片化的方法可能被证明是次优的，强调多领域干预的潜力-两种或更多种策略的组合，以改善个人健康-作为一个有前途的治疗选择。这篇综述探讨了多领域干预在少肌症中的可能作用。专门解决它们对肌肉质量和质量的影响，肌肉力量,和老年人的身体表现。虽然更新的文献强调了多领域干预在提高身体机能结果方面的有益后果，在了解它们对肌肉减少症生物学方面的影响方面仍然存在差距。有希望的初步发现表明血浆炎症标志物或肌肉更新网络的变化，但需要进一步的研究来阐明多领域干预对减少肌无力患者的疾病改善作用.
