PDF(Pubmed)
Abstract：
UNASSIGNED: To examine the impact of tobacco smoking on seminal parameters in men with both primary and secondary infertility.
UNASSIGNED: This cross-sectional study analyzed 1938 infertile men from China who were categorized as nonsmokers (n=1,067) and smokers (n=871), with the latter group further divided into moderate smokers (1-10 cigarettes per day) (n=568) and heavy smokers (>10 cigarettes per day) (n=303). We assessed semen volume, concentration, total sperm count, progressive motility, and normal morphology following World Health Organization (WHO 2010) guidelines. A logistic regression model was used to analyze the relationships between smoking and seminal parameters while also controlling for lifestyle factors.
UNASSIGNED: The analysis demonstrated a statistically significant correlation between smoking and adverse seminal parameters in both primary and secondary infertility patients. Specifically, primary infertile men who smoked had a lower semen concentration, with heavy smokers showing a median sperm concentration of 59.2×10^6/ml compared to 68.6×10^6/ml in nonsmokers (P=0.01). The secondary infertile men who smoked exhibited reduced forward sperm motility, with heavy smokers demonstrating a median progressive motility of 44.7%, which was significantly lower than the 48.1% observed in nonsmokers (P=0.04).
UNASSIGNED: Smoking is significantly associated with detrimental effects on seminal parameters in infertile men, thus highlighting the need for cessation programs as part of fertility treatment protocols. Encouraging smoking cessation could substantially improve semen quality and fertility outcomes in this population.
UNASSIGNED: This cross-sectional study analyzed 1938 infertile men from China who were categorized as nonsmokers (n=1,067) and smokers (n=871), with the latter group further divided into moderate smokers (1-10 cigarettes per day) (n=568) and heavy smokers (>10 cigarettes per day) (n=303). We assessed semen volume, concentration, total sperm count, progressive motility, and normal morphology following World Health Organization (WHO 2010) guidelines. A logistic regression model was used to analyze the relationships between smoking and seminal parameters while also controlling for lifestyle factors.
UNASSIGNED: The analysis demonstrated a statistically significant correlation between smoking and adverse seminal parameters in both primary and secondary infertility patients. Specifically, primary infertile men who smoked had a lower semen concentration, with heavy smokers showing a median sperm concentration of 59.2×10^6/ml compared to 68.6×10^6/ml in nonsmokers (P=0.01). The secondary infertile men who smoked exhibited reduced forward sperm motility, with heavy smokers demonstrating a median progressive motility of 44.7%, which was significantly lower than the 48.1% observed in nonsmokers (P=0.04).
UNASSIGNED: Smoking is significantly associated with detrimental effects on seminal parameters in infertile men, thus highlighting the need for cessation programs as part of fertility treatment protocols. Encouraging smoking cessation could substantially improve semen quality and fertility outcomes in this population.
摘要：
■研究吸烟对原发性和继发性不育男性精液参数的影响。
■这项横断面研究分析了1938名来自中国的不育男性，他们分为不吸烟者（n=1,067）和吸烟者（n=871）。后者进一步分为中度吸烟者（每天1-10支）（n=568）和重度吸烟者（每天>10支）（n=303）。我们评估了精液体积,浓度,精子总数,渐进运动，和正常形态遵循世界卫生组织（WHO2010）指南。使用逻辑回归模型分析吸烟与精液参数之间的关系，同时控制生活方式因素。
■分析表明，在原发性和继发性不孕症患者中，吸烟与不良精液参数之间存在统计学上的显着相关性。具体来说,吸烟的原发性不育男性精液浓度较低，重度吸烟者的精子浓度中位数为59.2×10^6/ml，而不吸烟者为68.6×10^6/ml（P=0.01）。吸烟的继发性不育男性表现出降低的向前精子活力，重度吸烟者的中位渐进运动率为44.7%，显著低于非吸烟者的48.1%(P=0.04)。
■吸烟与不育男性精液参数的有害影响显着相关，因此强调了将戒烟计划作为生育治疗方案的一部分的必要性。鼓励戒烟可以大大提高该人群的精液质量和生育能力。
■这项横断面研究分析了1938名来自中国的不育男性，他们分为不吸烟者（n=1,067）和吸烟者（n=871）。后者进一步分为中度吸烟者（每天1-10支）（n=568）和重度吸烟者（每天>10支）（n=303）。我们评估了精液体积,浓度,精子总数,渐进运动，和正常形态遵循世界卫生组织（WHO2010）指南。使用逻辑回归模型分析吸烟与精液参数之间的关系，同时控制生活方式因素。
■分析表明，在原发性和继发性不孕症患者中，吸烟与不良精液参数之间存在统计学上的显着相关性。具体来说,吸烟的原发性不育男性精液浓度较低，重度吸烟者的精子浓度中位数为59.2×10^6/ml，而不吸烟者为68.6×10^6/ml（P=0.01）。吸烟的继发性不育男性表现出降低的向前精子活力，重度吸烟者的中位渐进运动率为44.7%，显著低于非吸烟者的48.1%(P=0.04)。
■吸烟与不育男性精液参数的有害影响显着相关，因此强调了将戒烟计划作为生育治疗方案的一部分的必要性。鼓励戒烟可以大大提高该人群的精液质量和生育能力。
