PDF(Pubmed)
Abstract：
UNASSIGNED: To systematically evaluate the effect of vitamin D deficiency during pregnancy on neonatal adverse outcomes, such as preterm infants, low birth weight infants (LBWI), and small for gestational age (SGA) infants.
UNASSIGNED: A comprehensive literature search was conducted across multiple databases including PubMed, Embase, Cochrane Library, SinoMed, Wanfang Data Knowledge Service Platform, China National Knowledge Internet (CNKI), and VIP Chinese Science and Technology Journal Database (VIP). Following predefined inclusion and exclusion criteria, two researchers independently screened, extracted data, and assessed the quality of the included studies. Meta-analysis was performed using RevMan 5.4 and Stata 14 software to synthesize the findings.
UNASSIGNED: This study incorporated 13 cohort studies from 8 different countries and regions, encompassing a total of 55,162 pregnant women, among whom 28,155 were identified as having vitamin D deficiency. The Newcastle-Ottawa Scale (NOS) score ranged from 7-9 points. Meta-analysis results indicated a higher incidence of LBWI (OR = 5.52, 95% CI = 1.31-23.22. P = 0.02) in the group of pregnant women with vitamin D deficiency compared to those with adequate levels. However, there was no statistically significant difference in the likelihood of premature birth (OR = 1.25, 95% CI = 0.78-1.99. P = 0.36) or SGA (OR = 1.47, 95% CI = 0.81-2.68. P = 0.21) among newborns born to mothers with vitamin D deficiency vs. those with sufficient levels of vitamin D. Subgroup analysis based on the timing of maternal blood collection revealed that there was no statistically significant association between vitamin D levels during pregnancy and the incidence of preterm birth across all stages of pregnancy. Furthermore, vitamin D deficiency throughout the entire pregnancy was associated with an increased incidence of neonatal LBWI, whereas vitamin D levels during the first, second, and third trimesters did not demonstrate statistically differences on LBWI. Neonates born to mothers with vitamin D deficiency throughout pregnancy were found to have a higher likelihood of developing SGA. However, there was no statistically significant association between vitamin D levels and the development of SGA during the first and second trimesters.
UNASSIGNED: Adequate levels of vitamin D during pregnancy may decrease the incidence of LBWI, although further research is needed to determine its impact on the occurrence of preterm birth and SGA.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024535950, Identifier: (CRD42024535950).
UNASSIGNED: A comprehensive literature search was conducted across multiple databases including PubMed, Embase, Cochrane Library, SinoMed, Wanfang Data Knowledge Service Platform, China National Knowledge Internet (CNKI), and VIP Chinese Science and Technology Journal Database (VIP). Following predefined inclusion and exclusion criteria, two researchers independently screened, extracted data, and assessed the quality of the included studies. Meta-analysis was performed using RevMan 5.4 and Stata 14 software to synthesize the findings.
UNASSIGNED: This study incorporated 13 cohort studies from 8 different countries and regions, encompassing a total of 55,162 pregnant women, among whom 28,155 were identified as having vitamin D deficiency. The Newcastle-Ottawa Scale (NOS) score ranged from 7-9 points. Meta-analysis results indicated a higher incidence of LBWI (OR = 5.52, 95% CI = 1.31-23.22. P = 0.02) in the group of pregnant women with vitamin D deficiency compared to those with adequate levels. However, there was no statistically significant difference in the likelihood of premature birth (OR = 1.25, 95% CI = 0.78-1.99. P = 0.36) or SGA (OR = 1.47, 95% CI = 0.81-2.68. P = 0.21) among newborns born to mothers with vitamin D deficiency vs. those with sufficient levels of vitamin D. Subgroup analysis based on the timing of maternal blood collection revealed that there was no statistically significant association between vitamin D levels during pregnancy and the incidence of preterm birth across all stages of pregnancy. Furthermore, vitamin D deficiency throughout the entire pregnancy was associated with an increased incidence of neonatal LBWI, whereas vitamin D levels during the first, second, and third trimesters did not demonstrate statistically differences on LBWI. Neonates born to mothers with vitamin D deficiency throughout pregnancy were found to have a higher likelihood of developing SGA. However, there was no statistically significant association between vitamin D levels and the development of SGA during the first and second trimesters.
UNASSIGNED: Adequate levels of vitamin D during pregnancy may decrease the incidence of LBWI, although further research is needed to determine its impact on the occurrence of preterm birth and SGA.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024535950, Identifier: (CRD42024535950).
摘要：
■系统评估妊娠期维生素D缺乏对新生儿不良结局的影响，比如早产儿，低出生体重儿（LBWI），和小于胎龄儿(SGA)。
■在包括PubMed在内的多个数据库中进行了全面的文献检索，Embase,科克伦图书馆,SinoMed,万方数据知识服务平台,中国国民知识互联网(CNKI),和VIP中国科技期刊数据库（VIP）。遵循预定义的纳入和排除标准，两名研究人员独立筛选，提取的数据，并评估纳入研究的质量。使用RevMan5.4和Stata14软件进行荟萃分析以综合研究结果。
■本研究纳入了来自8个不同国家和地区的13项队列研究，共有55,162名孕妇,其中28,155人被确定为维生素D缺乏症。纽卡斯尔-渥太华量表（NOS）评分为7-9分。Meta分析结果显示LBWI发生率较高(OR=5.52,95%CI=1.31~23.22。与维生素D缺乏的孕妇相比，P=0.02）。然而,早产可能性差异无统计学意义(OR=1.25,95%CI=0.78-1.99.P=0.36)或SGA(OR=1.47,95%CI=0.81-2.68。P=0.21）在维生素D缺乏的母亲所生的新生儿中基于孕妇采血时间的亚组分析显示,妊娠期维生素D水平与妊娠所有阶段的早产发生率之间无统计学显著关联.此外，整个怀孕期间维生素D缺乏与新生儿LBWI的发病率增加有关，而维生素D水平在第一次，第二,妊娠晚期LBWI无统计学差异.发现整个怀孕期间维生素D缺乏的母亲所生的新生儿患SGA的可能性更高。然而,在孕早期和中期,维生素D水平与SGA的发展之间无统计学显著关联.
■怀孕期间维生素D的适当水平可以降低LBWI的发病率，尽管需要进一步的研究来确定其对早产和SGA发生的影响。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42024535950,标识符:(CRD42024535950)。
■在包括PubMed在内的多个数据库中进行了全面的文献检索，Embase,科克伦图书馆,SinoMed,万方数据知识服务平台,中国国民知识互联网(CNKI),和VIP中国科技期刊数据库（VIP）。遵循预定义的纳入和排除标准，两名研究人员独立筛选，提取的数据，并评估纳入研究的质量。使用RevMan5.4和Stata14软件进行荟萃分析以综合研究结果。
■本研究纳入了来自8个不同国家和地区的13项队列研究，共有55,162名孕妇,其中28,155人被确定为维生素D缺乏症。纽卡斯尔-渥太华量表（NOS）评分为7-9分。Meta分析结果显示LBWI发生率较高(OR=5.52,95%CI=1.31~23.22。与维生素D缺乏的孕妇相比，P=0.02）。然而,早产可能性差异无统计学意义(OR=1.25,95%CI=0.78-1.99.P=0.36)或SGA(OR=1.47,95%CI=0.81-2.68。P=0.21）在维生素D缺乏的母亲所生的新生儿中基于孕妇采血时间的亚组分析显示,妊娠期维生素D水平与妊娠所有阶段的早产发生率之间无统计学显著关联.此外，整个怀孕期间维生素D缺乏与新生儿LBWI的发病率增加有关，而维生素D水平在第一次，第二,妊娠晚期LBWI无统计学差异.发现整个怀孕期间维生素D缺乏的母亲所生的新生儿患SGA的可能性更高。然而,在孕早期和中期,维生素D水平与SGA的发展之间无统计学显著关联.
■怀孕期间维生素D的适当水平可以降低LBWI的发病率，尽管需要进一步的研究来确定其对早产和SGA发生的影响。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42024535950,标识符:(CRD42024535950)。
