PDF(Pubmed)
Abstract：
BACKGROUND: Cognitive reserve (CR) and the catechol-O-methyltransferase (COMT) Val/Met polymorphism are reportedly linked to negative symptoms in schizophrenia. However, the regulatory effect of the COMT genotype on the relationship between CR and negative symptoms is still unexamined.
OBJECTIVE: To investigate whether the relationship between CR and negative symptoms could be regulated by the COMT Val/Met polymorphism.
METHODS: In a cross-sectional study, 54 clinically stable patients with schizophrenia underwent assessments for the COMT genotype, CR, and negative symptoms. CR was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence Scale.
RESULTS: COMT Met-carriers exhibited fewer negative symptoms than Val homozygotes. In the total sample, significant negative correlations were found between negative symptoms and information, similarities. Associations between information, similarities and negative symptoms were observed in Val homozygotes only, with information and similarities showing interaction effects with the COMT genotype in relation to negative symptoms (information, β = -0.282, 95%CI: -0.552 to -0.011, P = 0.042; similarities, β = -0.250, 95%CI: -0.495 to -0.004, P = 0.046).
CONCLUSIONS: This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the COMT genotype in schizophrenia.
OBJECTIVE: To investigate whether the relationship between CR and negative symptoms could be regulated by the COMT Val/Met polymorphism.
METHODS: In a cross-sectional study, 54 clinically stable patients with schizophrenia underwent assessments for the COMT genotype, CR, and negative symptoms. CR was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence Scale.
RESULTS: COMT Met-carriers exhibited fewer negative symptoms than Val homozygotes. In the total sample, significant negative correlations were found between negative symptoms and information, similarities. Associations between information, similarities and negative symptoms were observed in Val homozygotes only, with information and similarities showing interaction effects with the COMT genotype in relation to negative symptoms (information, β = -0.282, 95%CI: -0.552 to -0.011, P = 0.042; similarities, β = -0.250, 95%CI: -0.495 to -0.004, P = 0.046).
CONCLUSIONS: This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the COMT genotype in schizophrenia.
摘要：
背景：据报道，认知储备（CR）和儿茶酚-O-甲基转移酶（COMT）Val/Met多态性与精神分裂症的阴性症状有关。然而,COMT基因型对CR与阴性症状之间关系的调节作用仍未研究.
目的：探讨COMTVal/Met多态性是否能调节CR与阴性症状之间的关系。
方法：在一项横断面研究中，54名临床稳定的精神分裂症患者接受了COMT基因型评估，CR,和阴性症状。CR是使用中文版Wechsler成人智力量表的简短形式的信息和相似性分测验中的分数来估计的。
结果：COMTMet携带者的阴性症状比Val纯合子少。在总样本中，阴性症状和信息之间存在显著负相关，相似性。信息之间的关联，仅在Val纯合子中观察到相似性和阴性症状，具有显示与阴性症状相关的COMT基因型相互作用的信息和相似性(信息，β=-0.282，95CI：-0.552至-0.011，P=0.042；相似性，β=-0.250，95CI：-0.495至-0.004，P=0.046）。
结论：这项研究提供了初步证据，证明精神分裂症阴性症状与CR之间的关联受COMT基因型的调节。
目的：探讨COMTVal/Met多态性是否能调节CR与阴性症状之间的关系。
方法：在一项横断面研究中，54名临床稳定的精神分裂症患者接受了COMT基因型评估，CR,和阴性症状。CR是使用中文版Wechsler成人智力量表的简短形式的信息和相似性分测验中的分数来估计的。
结果：COMTMet携带者的阴性症状比Val纯合子少。在总样本中，阴性症状和信息之间存在显著负相关，相似性。信息之间的关联，仅在Val纯合子中观察到相似性和阴性症状，具有显示与阴性症状相关的COMT基因型相互作用的信息和相似性(信息，β=-0.282，95CI：-0.552至-0.011，P=0.042；相似性，β=-0.250，95CI：-0.495至-0.004，P=0.046）。
结论：这项研究提供了初步证据，证明精神分裂症阴性症状与CR之间的关联受COMT基因型的调节。
