关键词: Streptococcus suis case report hearing loss meningitis metagenomic next-generation sequencing

Mesh : Humans Streptococcus suis / isolation & purification Male Middle Aged Streptococcal Infections / drug therapy China Meningitis, Bacterial / drug therapy diagnosis Anti-Bacterial Agents / therapeutic use Sepsis / drug therapy Hearing Loss, Sudden / etiology drug therapy

来  源:   DOI:10.3389/fpubh.2024.1369703   PDF(Pubmed)

Abstract:
UNASSIGNED: Streptococcus suis is one of the porcine pathogens that have recently emerged as a pathogen capable of causing zoonoses in some humans. Patients infected with S. suis can present with sepsis, meningitis, or arthritis. Compared to common pathogens, such as Meningococcus, Streptococcus pneumoniae, and Haemophilus influenzae, S. suis infections in humans have been reported only rarely.
UNASSIGNED: This case report described a 57-year-old man who presented with impaired consciousness and fever following several days of backache. He was a butcher who worked in an abattoir and had wounded his hands 2 weeks prior. The patient was dependent on alcohol for almost 40 years. S. suis was detected in the cerebrospinal fluid by metagenomic next-generation sequencing. Although he received adequate meropenem and low-dose steroid therapy, the patient suffered from bilateral sudden deafness after 5 days of the infection. The final diagnosis was S. suis meningitis and sepsis.
UNASSIGNED: The patient survived with hearing loss in both ears and dizziness at the 60-day follow-up.
UNASSIGNED: We reported a case of S. suis infection manifested as purulent meningitis and sepsis. Based on literature published worldwide, human S. suis meningitis shows an acute onset and rapid progression in the nervous system. Similar to bacterial meningitis, effective antibiotics, and low-dose steroids play important roles in the treatment of human S. suis meningitis.
摘要:
猪链球菌是猪病原体之一,最近已成为能够在某些人中引起人畜共患病的病原体。感染猪链球菌的患者可能会出现败血症,脑膜炎,或关节炎。与常见病原体相比,比如脑膜炎球菌,肺炎链球菌,和流感嗜血杆菌,人类猪链球菌感染的报道很少。
该病例报告描述了一名57岁的男子,他在几天的背痛后出现意识障碍和发热。他是一名屠夫,在屠宰场工作,两周前受伤。患者依赖酒精近40年。通过宏基因组下一代测序在脑脊液中检测到猪链球菌。尽管他接受了足够的美罗培南和低剂量类固醇治疗,该患者在感染5天后患有双侧突发性耳聋。最终诊断为猪链球菌脑膜炎和败血症。
患者在60天的随访中幸存下来,双耳听力损失和头晕。
我们报告一例猪链球菌感染,表现为化脓性脑膜炎和败血症。根据世界各地发表的文献,人类猪链球菌脑膜炎在神经系统中表现为急性发作和快速进展。类似于细菌性脑膜炎,有效的抗生素,低剂量类固醇在人类猪链球菌脑膜炎的治疗中起重要作用。
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