PDF(Pubmed)
Abstract：
BACKGROUND: Allium cepa, or onion, boosts numerous health benefits, including anti-diabetic effects. Its rich array of antioxidants and sulfur compounds not only aids heart health by lowering cholesterol and blood pressure but also exhibits anti-inflammatory properties. Onion\'s antibacterial and antiviral properties help combat infections, while its compounds like quercetin show promise in cancer prevention. Additionally, Allium cepa supports respiratory health by relieving coughs and colds and aids digestion with its prebiotic properties. Incorporating onions into a balanced diet can enhance overall well-being, including managing blood sugar levels in individuals with diabetes.
OBJECTIVE: This study aims to determine if the ethanolic extract from the dried peel of Allium cepa holds potential as an anti-diabetic agent, with a focus on its ability to manage diabetes and reduce blood sugar levels.
METHODS: To prepare the ethanolic extract from dried onion peel, the peel was finely ground and soaked in ethanol. The mixture was then agitated and filtered to separate the liquid extract. Finally, the filtrate was concentrated using methods such as rotary evaporation or vacuum distillation to obtain a concentrated extract for further analysis like alpha-amylase inhibition assay and alpha-glucosidase inhibition assay.
RESULTS: The ethanolic extracts derived from dried onion peel demonstrate inhibition of alpha-glucosidase, leading to reduced blood glucose levels. Additionally, this inhibition prompts an increase in insulin production.
CONCLUSIONS: The study underscores that the efficacy of the ethanolic extract of dried onion peel increases with concentration. It highlights the presence of beneficial compounds like total phenolics, flavonoids, quercetin, and its derivatives in onion peel, known for their therapeutic roles in cardiovascular health, weight management, diabetes control, cancer prevention, and antimicrobial activity. These findings affirm the hypoglycemic and anti-diabetic properties of Allium cepa\'s ethanolic leaf extract.
OBJECTIVE: This study aims to determine if the ethanolic extract from the dried peel of Allium cepa holds potential as an anti-diabetic agent, with a focus on its ability to manage diabetes and reduce blood sugar levels.
METHODS: To prepare the ethanolic extract from dried onion peel, the peel was finely ground and soaked in ethanol. The mixture was then agitated and filtered to separate the liquid extract. Finally, the filtrate was concentrated using methods such as rotary evaporation or vacuum distillation to obtain a concentrated extract for further analysis like alpha-amylase inhibition assay and alpha-glucosidase inhibition assay.
RESULTS: The ethanolic extracts derived from dried onion peel demonstrate inhibition of alpha-glucosidase, leading to reduced blood glucose levels. Additionally, this inhibition prompts an increase in insulin production.
CONCLUSIONS: The study underscores that the efficacy of the ethanolic extract of dried onion peel increases with concentration. It highlights the presence of beneficial compounds like total phenolics, flavonoids, quercetin, and its derivatives in onion peel, known for their therapeutic roles in cardiovascular health, weight management, diabetes control, cancer prevention, and antimicrobial activity. These findings affirm the hypoglycemic and anti-diabetic properties of Allium cepa\'s ethanolic leaf extract.
摘要：
背景：洋葱，或者洋葱,增加了许多健康益处，包括抗糖尿病作用。其丰富的抗氧化剂和硫化合物不仅通过降低胆固醇和血压来帮助心脏健康，而且还具有抗炎特性。洋葱的抗菌和抗病毒特性有助于对抗感染，而其化合物如槲皮素在预防癌症方面显示出希望。此外,洋葱通过缓解咳嗽和感冒来支持呼吸健康，并以益生元特性帮助消化。将洋葱纳入均衡饮食可以提高整体健康水平,包括管理糖尿病患者的血糖水平。
目的：本研究旨在确定洋葱干果皮的乙醇提取物是否具有抗糖尿病药的潜力，专注于其管理糖尿病和降低血糖水平的能力。
方法：从洋葱干皮中制备乙醇提取物，将果皮磨细并浸泡在乙醇中。然后搅拌混合物并过滤以分离液体提取物。最后,使用诸如旋转蒸发或真空蒸馏的方法浓缩滤液以获得浓缩的提取物用于进一步分析,如α-淀粉酶抑制测定和α-葡糖苷酶抑制测定。
结果：来自洋葱干果皮的乙醇提取物显示出抑制α-葡萄糖苷酶，导致血糖水平降低。此外,这种抑制作用促使胰岛素产量增加.
结论：该研究强调了干洋葱皮的乙醇提取物的功效随浓度的增加而增加。它强调了有益化合物的存在，如总酚类，黄酮类化合物，槲皮素,以及它在洋葱皮中的衍生物，以它们在心血管健康中的治疗作用而闻名，体重管理,糖尿病控制,癌症预防,和抗菌活性。这些发现肯定了洋葱乙醇叶提取物的降血糖和抗糖尿病特性。
目的：本研究旨在确定洋葱干果皮的乙醇提取物是否具有抗糖尿病药的潜力，专注于其管理糖尿病和降低血糖水平的能力。
方法：从洋葱干皮中制备乙醇提取物，将果皮磨细并浸泡在乙醇中。然后搅拌混合物并过滤以分离液体提取物。最后,使用诸如旋转蒸发或真空蒸馏的方法浓缩滤液以获得浓缩的提取物用于进一步分析,如α-淀粉酶抑制测定和α-葡糖苷酶抑制测定。
结果：来自洋葱干果皮的乙醇提取物显示出抑制α-葡萄糖苷酶，导致血糖水平降低。此外,这种抑制作用促使胰岛素产量增加.
结论：该研究强调了干洋葱皮的乙醇提取物的功效随浓度的增加而增加。它强调了有益化合物的存在，如总酚类，黄酮类化合物，槲皮素,以及它在洋葱皮中的衍生物，以它们在心血管健康中的治疗作用而闻名，体重管理,糖尿病控制,癌症预防,和抗菌活性。这些发现肯定了洋葱乙醇叶提取物的降血糖和抗糖尿病特性。
