PDF(Pubmed)
Abstract：
UNASSIGNED: This study investigated the effect of consumption of table eggs enriched with n-3 polyunsaturated fatty acids (n-3 PUFA), lutein, vitamin E and selenium on microvascular function, oxidative stress and inflammatory mediators in patients after acute coronary syndrome (ACS).
UNASSIGNED: In a prospective, randomized, interventional, double-blind clinical trial, ACS patients were assigned to either the Nutri4 (N=15, mean age: 57.2 ± 9.2 years), or the Control group (N=13; mean age 56.8 ± 9.6 years). The Nutri4 group consumed three enriched hen eggs daily for three weeks, providing approximately 1.785 mg of vitamin E, 0.330 mg of lutein, 0.054 mg of selenium and 438 mg of n-3 PUFAs. Biochemical parameters, including serum lipids, liver enzymes, nutrient concentrations, serum antioxidant enzyme activity (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)), and markers of oxidative stress (thiobarbituric acid reactive substances (TBARS) and ferric reducing ability (FRAP)), were assessed before and after the dietary interventions. Additionally, arterial blood pressure, heart rate, body composition, fluid status, anthropometric measurements, and skin microvascular blood flow responses to various stimuli (postocclusive reactive hyperemia (PORH), acetylcholine- (Ach ID), and sodium nitroprusside- (SNP ID)) were measured using laser Doppler flowmetry (LDF) throughout the study.
UNASSIGNED: The intake of Nutri4 eggs led to a significant reduction in LDL cholesterol levels, while the levels of total cholesterol remained within the established reference values. Consuming Nutri4 eggs resulted in a 12.7% increase in serum vitamin E levels, an 8.6% increase in selenium levels, and demonstrated a favorable impact on microvascular reactivity, as evidenced by markedly improved PORH and ACh ID. Nutri4 eggs exerted a significant influence on the activity of GPx and SOD, with no observed changes in TBARS or FRAP values.
UNASSIGNED: The consumption of Nutri4 eggs positively influenced microvascular function in individuals with ACS, without eliciting adverse effects on oxidative stress.
UNASSIGNED: In a prospective, randomized, interventional, double-blind clinical trial, ACS patients were assigned to either the Nutri4 (N=15, mean age: 57.2 ± 9.2 years), or the Control group (N=13; mean age 56.8 ± 9.6 years). The Nutri4 group consumed three enriched hen eggs daily for three weeks, providing approximately 1.785 mg of vitamin E, 0.330 mg of lutein, 0.054 mg of selenium and 438 mg of n-3 PUFAs. Biochemical parameters, including serum lipids, liver enzymes, nutrient concentrations, serum antioxidant enzyme activity (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)), and markers of oxidative stress (thiobarbituric acid reactive substances (TBARS) and ferric reducing ability (FRAP)), were assessed before and after the dietary interventions. Additionally, arterial blood pressure, heart rate, body composition, fluid status, anthropometric measurements, and skin microvascular blood flow responses to various stimuli (postocclusive reactive hyperemia (PORH), acetylcholine- (Ach ID), and sodium nitroprusside- (SNP ID)) were measured using laser Doppler flowmetry (LDF) throughout the study.
UNASSIGNED: The intake of Nutri4 eggs led to a significant reduction in LDL cholesterol levels, while the levels of total cholesterol remained within the established reference values. Consuming Nutri4 eggs resulted in a 12.7% increase in serum vitamin E levels, an 8.6% increase in selenium levels, and demonstrated a favorable impact on microvascular reactivity, as evidenced by markedly improved PORH and ACh ID. Nutri4 eggs exerted a significant influence on the activity of GPx and SOD, with no observed changes in TBARS or FRAP values.
UNASSIGNED: The consumption of Nutri4 eggs positively influenced microvascular function in individuals with ACS, without eliciting adverse effects on oxidative stress.
摘要：
■这项研究调查了食用富含n-3多不饱和脂肪酸（n-3PUFA）的食用鸡蛋的影响，叶黄素,维生素E和硒对微血管功能，急性冠脉综合征（ACS）后患者的氧化应激和炎症介质。
■在未来，随机化，介入,双盲临床试验,ACS患者被分配到Nutri4（N=15，平均年龄：57.2±9.2岁），或对照组（N=13；平均年龄56.8±9.6岁）。Nutri4组每天食用三个浓缩鸡蛋，持续三周，提供大约1.785毫克的维生素E，0.330毫克的叶黄素，0.054毫克硒和438毫克n-3PUFA。生化参数,包括血脂,肝酶，营养素浓度，血清抗氧化酶活性(过氧化氢酶(CAT)，谷胱甘肽过氧化物酶（GPx），超氧化物歧化酶（SOD）），和氧化应激标志物（硫代巴比妥酸反应性物质（TBARS）和三价铁还原能力（FRAP）），在饮食干预前后进行评估。此外,动脉血压,心率,身体成分,液体状态,人体测量,和皮肤微血管血流对各种刺激的反应（闭塞后反应性充血（PORH），乙酰胆碱-（AchID），和硝普钠（SNPID））在整个研究中使用激光多普勒血流仪（LDF）进行测量。
■Nutri4鸡蛋的摄入导致LDL胆固醇水平显着降低，而总胆固醇水平保持在既定参考值范围内。食用Nutri4鸡蛋导致血清维生素E水平增加12.7%，硒水平增加8.6%，并证明了对微血管反应性的有利影响，如显著改善PORH和AChID所证明。Nutri4鸡蛋对GPx和SOD活性有显著影响,没有观察到TBARS或FRAP值的变化。
■食用Nutri4鸡蛋对ACS患者的微血管功能有积极影响，不会引起对氧化应激的不利影响。
■在未来，随机化，介入,双盲临床试验,ACS患者被分配到Nutri4（N=15，平均年龄：57.2±9.2岁），或对照组（N=13；平均年龄56.8±9.6岁）。Nutri4组每天食用三个浓缩鸡蛋，持续三周，提供大约1.785毫克的维生素E，0.330毫克的叶黄素，0.054毫克硒和438毫克n-3PUFA。生化参数,包括血脂,肝酶，营养素浓度，血清抗氧化酶活性(过氧化氢酶(CAT)，谷胱甘肽过氧化物酶（GPx），超氧化物歧化酶（SOD）），和氧化应激标志物（硫代巴比妥酸反应性物质（TBARS）和三价铁还原能力（FRAP）），在饮食干预前后进行评估。此外,动脉血压,心率,身体成分,液体状态,人体测量,和皮肤微血管血流对各种刺激的反应（闭塞后反应性充血（PORH），乙酰胆碱-（AchID），和硝普钠（SNPID））在整个研究中使用激光多普勒血流仪（LDF）进行测量。
■Nutri4鸡蛋的摄入导致LDL胆固醇水平显着降低，而总胆固醇水平保持在既定参考值范围内。食用Nutri4鸡蛋导致血清维生素E水平增加12.7%，硒水平增加8.6%，并证明了对微血管反应性的有利影响，如显著改善PORH和AChID所证明。Nutri4鸡蛋对GPx和SOD活性有显著影响,没有观察到TBARS或FRAP值的变化。
■食用Nutri4鸡蛋对ACS患者的微血管功能有积极影响，不会引起对氧化应激的不利影响。
