PDF(Pubmed)
Abstract：
Excessive fluoride intake from residential environments may affect multiple tissues and organs; however, the specific pathogenic mechanisms are unclear. Researchers have recently focused on the damaging effects of fluoride on the immune system. Damage to immune function seriously affects the quality of life of fluoride-exposed populations and increases the incidence of infections and malignant tumors. Probing the mechanism of damage to immune function caused by fluoride helps identify effective drugs and methods to prevent and treat fluorosis and improve people\'s living standards in fluorosis-affected areas. Here, the recent literature on the effects of fluoride on the immune system is reviewed, and research on fluoride damage to the immune system is summarized in terms of three perspectives: immune organs, immune cells, and immune-active substances. We reviewed that excessive fluoride can damage immune organs, lead to immune cells dysfunction and interfere with the expression of immune-active substances. This review aimed to provide a potential direction for future fluorosis research from the perspective of fluoride-induced immune function impairment. In order to seek the key regulatory indicators of fluoride on immune homeostasis in the future.
摘要：
从居住环境中摄入过多的氟化物可能会影响多个组织和器官；然而，具体致病机制尚不清楚。研究人员最近专注于氟化物对免疫系统的破坏性影响。免疫功能受损严重影响氟暴露人群的生活质量，增加感染和恶性肿瘤的发生率。探讨氟对免疫功能损害的机制,有助于找出防治氟中毒的有效药物和方法,提高氟中毒疫区人民的生活水平。这里,综述了有关氟化物对免疫系统影响的最新文献，氟对免疫系统损伤的研究从三个角度进行了总结:免疫器官,免疫细胞，和免疫活性物质。我们回顾了过量的氟化物会损害免疫器官，导致免疫细胞功能紊乱,干扰免疫活性物质的表达。本文旨在从氟诱导的免疫功能损害的角度为未来氟中毒的研究提供一个潜在的方向。以寻求未来氟化物对免疫稳态的关键调控指标。
