PDF(Pubmed)
Abstract：
Ten novel spectrophotometric approaches were developed for the initial examination of the Hydroxychloroquine and Paracetamol medications. These procedures are straightforward, specific, easy to use, and provide exact and accurate results. The determination was conducted through the utilization of several approaches, including zero order (dual wavelength, zero crossing, advanced absorption subtraction and spectrum subtraction), derivative (first derivative of zero crossing), ratio (ratio difference, ratio derivative) and mathematical (bivariate, simultaneous equation, and Q-absorbance) techniques. After undergoing validation in accordance with ICH criteria, it was established that each of these methods achieved acceptable levels of precision, repeatability, robustness, and accuracy. The advantages and disadvantages of each method are demonstrated, and the proposed and reported methodologies were statistically compared.
摘要：
开发了十种新颖的分光光度法，用于对羟氯喹和扑热息痛药物进行初步检查。这些程序很简单，具体,易于使用,并提供准确准确的结果。确定是通过利用几种方法进行的，包括零阶(双波长，过零点,先进的吸收减法和频谱减法)，导数（零交叉的一阶导数），比率(比率差，比率导数)和数学(双变量，联立方程，和Q吸光度)技术。根据ICH标准进行验证后，已经确定，这些方法中的每一种都达到了可接受的精度水平，重复性,鲁棒性，和准确性。证明了每种方法的优缺点，并对提出的方法和报告的方法进行了统计比较。
