PDF(Pubmed)
Abstract：
Polyetheretherketone (PEEK) is considered as an excellent biomaterial for bone grafting and connective tissue replacement. The clinical potential is, however, limited by its bioinertness, poor osteoconduction, and weak antibacterial activity. These disadvantages can be overcome by introducing suitable additives to produce mineral-polymer composites or coatings. In this work, a PEEK-based bioactive composite has been obtained by blending the polymer with magnesium phosphate (Mg3(PO4)2) particles in amounts ranging from 1 to 10 wt.% using the hot press technique. The obtained composite exhibited improved mechanical and physical properties, above the lower limits set for bone engineering applications. The tested grafts were found to not induce cytotoxicity. The presence of magnesium phosphate induced the mineralisation process with no adverse effects on the expression of the marker crucial for osteoblastic differentiation. The most promising results were observed in the grafts containing 1 wt.% of magnesium phosphate embedded within the PEEK matrix. The improved bioactivity of grafts, together with suitable physical-chemical and mechanical properties, indicate this composite as a promising orthopaedic implant material.
摘要：
聚醚醚酮（PEEK）被认为是骨移植和结缔组织替代的优良生物材料。临床潜力是,然而,受限于其生物惰性，骨传导不良，和弱的抗菌活性。这些缺点可以通过引入合适的添加剂以制备矿物-聚合物复合材料或涂层来克服。在这项工作中,基于PEEK的生物活性复合材料是通过将聚合物与磷酸镁(Mg3(PO4)2)颗粒以1至10重量%的量共混而获得的。%采用热压技术。获得的复合材料表现出改善的机械和物理性能，高于为骨骼工程应用设定的下限。发现测试的移植物不诱导细胞毒性。磷酸镁的存在诱导了矿化过程，对成骨细胞分化至关重要的标志物的表达没有不利影响。在含有1wt。的移植物中观察到最有希望的结果。%的磷酸镁包埋在PEEK基质内。移植物生物活性的提高，以及合适的物理化学和机械性能，表明这种复合材料是一种有前途的骨科植入材料。
