PDF(Pubmed)
Abstract：
OBJECTIVE: People with mustard gas lung disease experience cough, sputum, breathlessness and exercise limitation. We hypothesised that pulmonary rehabilitation (PR) would be beneficial in this condition.
METHODS: An assessor-blind, two-armed, parallel-design randomised controlled clinical trial.
METHODS: Secondary care clinics in Iran.
METHODS: 60 men with breathlessness due to respiratory disease caused by documented mustard gas exposure, mean (SD) age 52.7 (4.36) years, MRC dyspnoea score 3.5 (0.7), St. George\'s Respiratory Questionnaire (SGRQ) 72.3 (15.2).
METHODS: Participants were allocated either to a 6-week course of thrice-weekly PR (n=31) or to usual care (n=29), with 6-week data for 28 and 26, respectively.
METHODS: Primary endpoint was change in cycle endurance time at 70% baseline exercise capacity at 6 weeks. Secondary endpoints included 6 min walk distance, quadriceps strength and bulk, body composition and health status. For logistical reasons, blood tests that had been originally planned were not performed and 12-month follow-up was available for only a small proportion.
RESULTS: At 6 weeks, cycle endurance time increased from 377 (140) s to 787 (343) s with PR vs 495 (171) s to 479 (159) s for usual care, effect size +383 (231) s (p<0.001). PR also improved 6 min walk distance+103.2 m (63.6-142.9) (p<0.001), MRC dyspnoea score -0.36 (-0.65 to -0.07) (p=0.016) and quality of life; SGRQ -8.43 (-13.38 to -3.48) p<0.001, as well as quadriceps strength+9.28 Nm (1.89 to 16.66) p=0.015.
CONCLUSIONS: These data suggest that PR can improve exercise capacity and quality of life in people with breathlessness due to mustard gas lung disease and support the wider provision of this form of care.
BACKGROUND: IRCT2016051127848N1.
METHODS: An assessor-blind, two-armed, parallel-design randomised controlled clinical trial.
METHODS: Secondary care clinics in Iran.
METHODS: 60 men with breathlessness due to respiratory disease caused by documented mustard gas exposure, mean (SD) age 52.7 (4.36) years, MRC dyspnoea score 3.5 (0.7), St. George\'s Respiratory Questionnaire (SGRQ) 72.3 (15.2).
METHODS: Participants were allocated either to a 6-week course of thrice-weekly PR (n=31) or to usual care (n=29), with 6-week data for 28 and 26, respectively.
METHODS: Primary endpoint was change in cycle endurance time at 70% baseline exercise capacity at 6 weeks. Secondary endpoints included 6 min walk distance, quadriceps strength and bulk, body composition and health status. For logistical reasons, blood tests that had been originally planned were not performed and 12-month follow-up was available for only a small proportion.
RESULTS: At 6 weeks, cycle endurance time increased from 377 (140) s to 787 (343) s with PR vs 495 (171) s to 479 (159) s for usual care, effect size +383 (231) s (p<0.001). PR also improved 6 min walk distance+103.2 m (63.6-142.9) (p<0.001), MRC dyspnoea score -0.36 (-0.65 to -0.07) (p=0.016) and quality of life; SGRQ -8.43 (-13.38 to -3.48) p<0.001, as well as quadriceps strength+9.28 Nm (1.89 to 16.66) p=0.015.
CONCLUSIONS: These data suggest that PR can improve exercise capacity and quality of life in people with breathlessness due to mustard gas lung disease and support the wider provision of this form of care.
BACKGROUND: IRCT2016051127848N1.
摘要：
目标：患有芥子气肺病的人出现咳嗽，痰,呼吸困难和运动受限。我们假设肺康复（PR）在这种情况下是有益的。
方法：评估者盲，双臂,平行设计随机对照临床试验。
方法：位于伊朗的二级保健诊所。
方法：60名男性因记录的芥子气暴露引起的呼吸道疾病而呼吸困难，平均（SD）年龄52.7（4.36）岁，MRC呼吸困难评分3.5（0.7），圣乔治呼吸问卷（SGRQ）72.3（15.2）。
方法：参与者被分配到为期6周的每周三次PR（n=31）或常规护理（n=29），分别为28和26的6周数据。
方法：主要终点是在6周时70％基线运动能力下的循环耐力时间的变化。次要终点包括6分钟步行距离，股四头肌强度和体积，身体成分和健康状况。出于后勤原因,没有进行原计划的血液检查,只有一小部分人可以进行12个月的随访.
结果：在第6周，循环耐久时间从377(140)s增加到787(343)s，PR比495(171)s增加到479(159)s，效应大小+383(231)s(p<0.001)。PR还提高了6分钟步行距离+103.2m(63.6-142.9)(p<0.001)，MRC呼吸困难评分-0.36（-0.65至-0.07）（p=0.016）和生活质量；SGRQ-8.43（-13.38至-3.48）p<0.001，以及股四头肌强度9.28Nm（1.89至16.66）p=0.015。
结论：这些数据表明，PR可以改善因芥子气肺病而呼吸困难的人的运动能力和生活质量，并支持更广泛地提供这种形式的护理。
背景：IRCT2016051127848N1.
方法：评估者盲，双臂,平行设计随机对照临床试验。
方法：位于伊朗的二级保健诊所。
方法：60名男性因记录的芥子气暴露引起的呼吸道疾病而呼吸困难，平均（SD）年龄52.7（4.36）岁，MRC呼吸困难评分3.5（0.7），圣乔治呼吸问卷（SGRQ）72.3（15.2）。
方法：参与者被分配到为期6周的每周三次PR（n=31）或常规护理（n=29），分别为28和26的6周数据。
方法：主要终点是在6周时70％基线运动能力下的循环耐力时间的变化。次要终点包括6分钟步行距离，股四头肌强度和体积，身体成分和健康状况。出于后勤原因,没有进行原计划的血液检查,只有一小部分人可以进行12个月的随访.
结果：在第6周，循环耐久时间从377(140)s增加到787(343)s，PR比495(171)s增加到479(159)s，效应大小+383(231)s(p<0.001)。PR还提高了6分钟步行距离+103.2m(63.6-142.9)(p<0.001)，MRC呼吸困难评分-0.36（-0.65至-0.07）（p=0.016）和生活质量；SGRQ-8.43（-13.38至-3.48）p<0.001，以及股四头肌强度9.28Nm（1.89至16.66）p=0.015。
结论：这些数据表明，PR可以改善因芥子气肺病而呼吸困难的人的运动能力和生活质量，并支持更广泛地提供这种形式的护理。
背景：IRCT2016051127848N1.
