Abstract：
Molecular motor amphiphiles have already been widely attempted for dynamic nanosystems across multiple length-scale for developments of small functional materials, including controlling macroscopic foam properties, amplifying motion as artificial molecular muscles, and serving as extracellular matrix mimicking cell scaffolds. However, limiting examples of bola-type molecular motor amphiphiles are considered for constructing macroscopic biomaterials. Herein, this work presents the designed two second generation molecular motor amphiphiles, motor bola-amphiphiles (MBAs). Aside from the photoinduced motor rotation of MBAs achieved in both organic and aqueous media, the rate of recovering thermal helix inversion step can be controlled by the rotor part with different steric hindrances. Dynamic assembled structures of MBAs are observed under (cryo)-transmission electron microscopy (TEM). This dynamicity assists MBAs in further assembling as macroscopic soft scaffolds by applying a shear-flow method. Upon photoirradiation, the phototropic bending function of MBA scaffolds is observed, demonstrating the amplification of molecular motion into macroscopic phototropic bending functions at the macroscopic length-scale. Since MBAs are confirmed with low cytotoxicity, human bone marrow-derived mesenchymal stem cells (hBM-MSCs) can grow on the surface of MBA scaffolds. These results clearly demonstrate the concept of designing MBAs for developing photoresponsive dynamic functional materials to create new-generation soft robotic systems and cell-material interfaces.
摘要：
分子马达两亲物已经被广泛尝试用于多个长度尺度的动态纳米系统，以开发小型功能材料。包括控制宏观泡沫性能，作为人造分子肌肉放大运动，并作为模拟细胞支架的细胞外基质。然而,bola型分子马达两亲物的限制性例子被认为用于构建宏观生物材料。在这里，我们提出了我们设计的两种第二代分子马达两亲物，马达Bola-两栖动物(MBA)。除了在有机和水性介质中实现的MBAs的光诱导电机旋转之外，热螺旋反转步骤的恢复速率可以通过具有不同空间位阻的转子部分来控制。在（低温）透射电子显微镜下观察到MBAs的动态组装结构。这种动态性有助于MBAs通过应用剪切流方法进一步组装为宏观软支架。光照射后，观察到MBA支架的光致弯曲功能，在宏观长度尺度上证明了分子运动放大为宏观向光弯曲功能。由于MBAs被证实具有低细胞毒性，人骨髓间充质干细胞可以在MBA支架表面生长。这些结果清楚地证明了设计用于开发光响应动态功能材料以创建新一代软机器人系统和细胞-材料界面的MBA的概念。本文受版权保护。保留所有权利。
