Abstract：
OBJECTIVE: Validation of a contemporary International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) congenital esophageal atresia/tracheoesophageal atresia (EA/TEF) cohort in the Pediatric Health Information System (PHIS) database.
METHODS: Database study, validation.
METHODS: Tertiary care center.
METHODS: Search methods used to validate an ICD-9-CM EA/TEF cohort in PHIS were modified for ICD-10-CM. A retrospectively and prospectively maintained clinical database at a single high-volume EA/TEF center was used for comparison. Patients treated between October 1, 2015 and July 31, 2022 were included. Searches progressively narrowed the cohort by ICD-10-CM diagnosis codes, expansion to include incorrectly coded as \'iatrogenic, age less than 30 days, and use of at least 1 ICD-10-CM procedure code. Results of PHIS data and institution data were compared for accuracy.
RESULTS: The most refined search of PHIS and the EA/TEF clinical database yielded 93 and 84 patients, respectively. The sensitivity was 99% and positive predictive value was 94%. A PHIS search using these methods and encompassing 49 children\'s hospitals yielded an EA/TEF cohort of 2479 patients.
CONCLUSIONS: We present a validated search method in the PHIS database to identify a high-fidelity cohort of EA/TEF patients for multi-institutional study. We have demonstrated that a carefully maintained clinical database may be used to validate cohorts in PHIS. This cohort allows for improved practice variability and outcomes study of EA/TEF patients. Similar methods may be employed to generate other rare disease cohorts in PHIS.
METHODS: Level 4.
METHODS: Database study, validation.
METHODS: Tertiary care center.
METHODS: Search methods used to validate an ICD-9-CM EA/TEF cohort in PHIS were modified for ICD-10-CM. A retrospectively and prospectively maintained clinical database at a single high-volume EA/TEF center was used for comparison. Patients treated between October 1, 2015 and July 31, 2022 were included. Searches progressively narrowed the cohort by ICD-10-CM diagnosis codes, expansion to include incorrectly coded as \'iatrogenic, age less than 30 days, and use of at least 1 ICD-10-CM procedure code. Results of PHIS data and institution data were compared for accuracy.
RESULTS: The most refined search of PHIS and the EA/TEF clinical database yielded 93 and 84 patients, respectively. The sensitivity was 99% and positive predictive value was 94%. A PHIS search using these methods and encompassing 49 children\'s hospitals yielded an EA/TEF cohort of 2479 patients.
CONCLUSIONS: We present a validated search method in the PHIS database to identify a high-fidelity cohort of EA/TEF patients for multi-institutional study. We have demonstrated that a carefully maintained clinical database may be used to validate cohorts in PHIS. This cohort allows for improved practice variability and outcomes study of EA/TEF patients. Similar methods may be employed to generate other rare disease cohorts in PHIS.
METHODS: Level 4.
摘要：
目的：验证当代国际疾病分类，第十次修订,儿科健康信息系统（PHIS）数据库中的临床修改（ICD-10-CM）先天性食管闭锁/气管食管闭锁（EA/TEF）队列。
方法：数据库研究，验证。
方法：三级护理中心。
方法：用于验证PHIS中ICD-9-CMEA/TEF队列的搜索方法被修改为ICD-10-CM。使用单个高容量EA/TEF中心的回顾性和前瞻性维护的临床数据库进行比较。纳入2015年10月1日至2022年7月31日期间接受治疗的患者。搜索通过ICD-10-CM诊断代码逐渐缩小队列，扩展包括错误编码为医源性，年龄小于30天，并使用至少1个ICD-10-CM程序码。比较PHIS数据和机构数据的结果的准确性。
结果：对PHIS和EA/TEF临床数据库的最精细搜索产生了93名和84名患者，分别。敏感性为99%，阳性预测值为94%。使用这些方法并涵盖49家儿童医院的PHIS搜索产生了2479名患者的EA/TEF队列。
结论：我们在PHIS数据库中提出了一种经过验证的搜索方法，以确定用于多机构研究的EA/TEF患者的高保真队列。我们已经证明，精心维护的临床数据库可用于验证PHIS中的队列。该队列允许改进EA/TEF患者的实践变异性和结果研究。可以采用类似的方法来产生PHIS中的其他罕见疾病队列。
方法：第4级。
方法：数据库研究，验证。
方法：三级护理中心。
方法：用于验证PHIS中ICD-9-CMEA/TEF队列的搜索方法被修改为ICD-10-CM。使用单个高容量EA/TEF中心的回顾性和前瞻性维护的临床数据库进行比较。纳入2015年10月1日至2022年7月31日期间接受治疗的患者。搜索通过ICD-10-CM诊断代码逐渐缩小队列，扩展包括错误编码为医源性，年龄小于30天，并使用至少1个ICD-10-CM程序码。比较PHIS数据和机构数据的结果的准确性。
结果：对PHIS和EA/TEF临床数据库的最精细搜索产生了93名和84名患者，分别。敏感性为99%，阳性预测值为94%。使用这些方法并涵盖49家儿童医院的PHIS搜索产生了2479名患者的EA/TEF队列。
结论：我们在PHIS数据库中提出了一种经过验证的搜索方法，以确定用于多机构研究的EA/TEF患者的高保真队列。我们已经证明，精心维护的临床数据库可用于验证PHIS中的队列。该队列允许改进EA/TEF患者的实践变异性和结果研究。可以采用类似的方法来产生PHIS中的其他罕见疾病队列。
方法：第4级。
