PDF(Pubmed)
Abstract：
The vagina is an essential component of the female reproductive system and is responsible for providing female sexual satisfaction. Vaginal smooth muscle contraction plays a crucial role in various physiological processes, including sexual arousal, childbirth, and urinary continence. In pathophysiological conditions, such as pelvic floor disorders, aberrations in vaginal smooth muscle function can lead to urinary incontinence and pelvic organ prolapse. A set of cellular and sub-cellular physiological mechanisms regulates the contractile properties of the vaginal smooth muscle cells. Calcium influx is a crucial determinant of smooth muscle contraction, facilitated through voltage-dependent calcium channels and calcium release from intracellular stores. Comprehensive reviews on smooth muscle biophysics are relatively scarce within the scientific literature, likely due to the complexity and specialized nature of the topic. The objective of this review is to provide a comprehensive description of alterations in the cellular physiology of vaginal smooth muscle contraction. The benefit associated with this particular approach is that conducting a comprehensive examination of the cellular mechanisms underlying contractile activation will enable the creation of more targeted therapeutic agents to control vaginal contraction disorders.
摘要：
阴道是女性生殖系统的重要组成部分，负责提供女性性满意度。阴道平滑肌收缩在各种生理过程中起着至关重要的作用,包括性唤起,分娩,和尿失禁。在病理生理条件下，如盆底疾病，阴道平滑肌功能异常可导致尿失禁和盆腔器官脱垂。一组细胞和亚细胞生理机制调节阴道平滑肌细胞的收缩特性。钙的流入是决定平滑肌收缩的关键因素,通过电压依赖性钙通道和从细胞内储存的钙释放促进。在科学文献中，关于平滑肌生物物理学的综合评论相对较少，可能是由于主题的复杂性和专业性。这篇综述的目的是全面描述阴道平滑肌收缩的细胞生理学改变。与该特定方法相关的益处是,对收缩激活基础的细胞机制进行全面检查将能够产生更有针对性的治疗剂来控制阴道收缩障碍。
