PDF(Pubmed)
Abstract：
There has been emerging research linking per- and poly-fluoroalkyl substances (PFAS) to gamete viability and fertility. PFAS, prevalent in the environment and water supplies, undergo slow degradation due to their C-F bond and a long half-life (2.3-8.5 years). In females, PFAS inhibit the hypothalamic-pituitary-gonadal (HPG) axis, reducing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, leading to the inhibition of androgen and estradiol production. PFAS have been found to cause detrimental effects on egg quality through impairing folliculogenesis. In males, PFAS can impair sperm motility and morphology: two fundamental qualities of successful fertilization. PFAS exposure has been proven to inhibit testosterone production, sperm capacitation, and acrosomal reaction. After fertilization, the results of PFAS exposure to embryos have also been investigated, showing reduced development to the blastocyst stage. The aim of this review is to report the main findings in the literature on the impact of PFAS exposure to gamete competency and fertilization capability by highlighting key studies on both male and female fertility. We report that there is significant evidence demonstrating the negative impacts on fertility after PFAS exposure. At high doses, these environmentally abundant and widespread compounds can significantly affect human fertility.
摘要：
已经有新的研究将全氟烷基和多氟烷基物质（PFAS）与配子生存力和生育力联系起来。PFAS,在环境和水供应中普遍存在，由于其C-F键和长半衰期（2.3-8.5年），因此降解缓慢。在女性中，PFAS抑制下丘脑-垂体-性腺（HPG）轴，降低卵泡刺激素（FSH）和黄体生成素（LH）水平，导致抑制雄激素和雌二醇的产生。已经发现PFAS通过损害卵泡生成对卵子质量造成不利影响。在男性中，PFAS会损害精子活力和形态：成功受精的两个基本素质。PFAS暴露已被证明可以抑制睾酮的产生，精子获能,和顶体反应。受精后,PFAS暴露于胚胎的结果也得到了调查，显示发育减少到胚泡阶段。这篇综述的目的是通过强调对男性和女性生育能力的关键研究，报告文献中关于PFAS暴露对配子能力和受精能力的影响的主要发现。我们报告说，有大量证据表明PFAS暴露后对生育率的负面影响。在高剂量下，这些环境丰富和广泛存在的化合物会显著影响人类的生育能力。
