Abstract：
Voice prostheses are known to fail in few weeks to several months of implantation due to the clogging mainly caused by microbial biofilm formation, which is a cause of concern. Iodine is a known broad-spectrum biocide and is reported to easily form complexes with various polymers. For long term device disinfection, strong iodine complexation that offers sustained iodine release for a prolonged period is essential. The present research work deals with the synthesis of a poly(methyl methacrylate-n-butyl acrylate-N-vinyl-2-pyrrolidone) (poly[MMA-BA-NVP]) tercopolymer through free radical polymerization for surface coating thermoplastic polyurethane (TPU) based voice prostheses. The NVP content in the tercopolymer was varied from 20% to 50% to optimise iodine loading and subsequent release. Base TPU coated with the tercopolymer was treated with 4% aqueous iodine solution at room temperature (28 ± 3 °C) for two hours. It was observed that the tercopolymer containing 35% N-vinyl-2-pyrrolidone (NVP), 32.5% methyl methacrylate (MMA) and 32.5% butyl acrylate (nBA) gave a stable coating on TPUs together with sustained iodine release for a prolonged period. Furthermore, the tercopolymer coated and iodine loaded TPUs exhibited excellent antimicrobial activity against Candida albicans, Staphylococcus aureus and Escherichia coli.
摘要：
众所周知，由于主要由微生物生物膜形成引起的堵塞，语音假体在植入的几周至几个月内失败。这令人担忧。碘是已知的广谱杀生物剂,并且据报道容易与各种聚合物形成络合物。长期设备消毒，强烈的碘络合，提供持续的碘释放延长时期是必不可少的。本研究工作涉及通过自由基聚合合成聚（甲基丙烯酸甲酯-丙烯酸正丁酯-N-乙烯基-2-吡咯烷酮）（聚[MMA-BA-NVP]）三元共聚物，用于表面涂覆热塑性聚氨酯（TPU）基语音假体。三元共聚物中的NVP含量从20%变化到50%以优化碘负载和随后的释放。在室温(28±3°C)下用4%碘水溶液处理涂覆有三元共聚物的基础TPU2小时。观察到含有35%N-乙烯基-2-吡咯烷酮(NVP)的三元共聚物,32.5%的甲基丙烯酸甲酯(MMA)和32.5%的丙烯酸丁酯(nBA)在TPU上给出稳定的涂层,同时持续长时间地释放碘。此外，三元共聚物涂层和碘负载的TPU对白色念珠菌表现出优异的抗菌活性，金黄色葡萄球菌和大肠杆菌。
