Abstract：
Corneal transplantation can restore visual function when visual impairment is caused by a corneal disease. However, this treatment is associated with the scarcity of cornea donors. The suitability of corneal donation from patients with glaucoma using ocular hypotensive agents (OHAs) is controversial. This study aimed to elucidate changes in corneal thickness, corneal endothelial cell density, and corneal endothelial cell hexagonality after OHA use in patients with primary open-angle glaucoma. We retrospectively reviewed the data of 53 glaucoma suspect eyes without OHA use and 106 primary open-angle glaucoma eyes under OHA use. All participants underwent corneal parameter assessment using SP-3000P (Topcon Corp., Tokyo, Japan) at the time of diagnosis and the final visit. The OHA dose and timing of use were recorded. The ocular hypotensive agents score (OHAS) was determined based on the number, formula, frequency, and duration of OHA use. Baseline data showed no significant differences between the two groups with and without OHA use. At the final visit, the OHA-treated group showed significantly lower corneal thickness and corneal endothelial cell density than those of the control group. A weak positive correlation between the OHAS and changes in corneal endothelial cell hexagonality was noted. However, no correlation was observed between the OHAS and changes in corneal thickness or endothelial cell density. In conclusion, patients with glaucoma and using OHAs should undergo the corneal structural properties examinations before donation to ensure the quality of donor cornea.
摘要：
当角膜疾病引起视力障碍时，角膜移植可以恢复视觉功能。然而,这种治疗与角膜供体的稀缺有关。使用降眼压剂（OHAs）从青光眼患者中捐赠角膜的适用性存在争议。本研究旨在阐明角膜厚度的变化，角膜内皮细胞密度，原发性开角型青光眼患者使用OHA后的角膜内皮细胞六角形。我们回顾性分析了53例未使用OHA的可疑青光眼眼和106例未使用OHA的原发性开角型青光眼眼的数据。所有参与者都使用SP-3000P（TopconCorp.,东京,日本）在诊断和最终访问时。记录OHA剂量和使用时间。根据数字确定眼压药物评分（OHAS），公式，频率,以及OHA使用的持续时间。基线数据显示，使用和不使用OHA的两组之间没有显着差异。在最后一次访问中,OHA治疗组的角膜厚度和角膜内皮细胞密度明显低于对照组.注意到OHAS与角膜内皮细胞六角形的变化之间存在弱正相关。然而,OHAS与角膜厚度或内皮细胞密度的变化无相关性.总之,青光眼患者和使用OHAs的患者在捐献前应进行角膜结构特性检查，以确保供体角膜的质量。
