PDF(Pubmed)
Abstract：
UNASSIGNED: Postoperative atrial fibrillation (POAF) is considered the most prevalent irregular heart rhythm after heart surgery. The cardiac autonomic nervous system significantly affects POAF, and neuropeptide Y (NPY), an abundant neuropeptide in the cardiovascular system, is involved in this autonomic regulation. The current work aimed to examine the potential association of NPY with POAF in individuals administered isolated off-pump coronary artery bypass grafting.
UNASSIGNED: From January 1 to May 31, 2020, we examined consecutive cases administered successful isolated off-pump coronary artery bypass grafting with no previously diagnosed atrial fibrillation (AF). Clinical characteristics and plasma samples were collected before surgery. NPY was quantified by enzyme-linked immunosorbent assay (ELISA) in peripheral blood, and POAF cases were identified through a 7-day Holter monitoring.
UNASSIGNED: Among 120 cases with no previously diagnosed AF, 33 (27.5 %) developed POAF during hospitalization. Median NPY levels were markedly elevated in the POAF group in comparison with the sinus rhythm group (31.72 vs. 27.95, P = 0.014). Multivariable logistic regression analysis revealed age (OR = 1.135, 95%CI 1.054-1.223; P = 0.001), left atrial size (OR = 1.136, 95%CI 1.004-1.285; P = 0.043), and NPY levels in peripheral blood (OR = 1.055, 95%CI 1.002-1.111; p = 0.041) independently predicted POAF. Additionally, NPY levels were positively correlated with high-frequency (HF) (r = 0.2774, P = 0.0022) and low-frequency (LF) (r = 0.2095, P = 0.0217) components of heart rate variability.
UNASSIGNED: In summary, this study demonstrates an association between elevated NPY levels in peripheral blood before surgery and POAF occurrence.
UNASSIGNED: From January 1 to May 31, 2020, we examined consecutive cases administered successful isolated off-pump coronary artery bypass grafting with no previously diagnosed atrial fibrillation (AF). Clinical characteristics and plasma samples were collected before surgery. NPY was quantified by enzyme-linked immunosorbent assay (ELISA) in peripheral blood, and POAF cases were identified through a 7-day Holter monitoring.
UNASSIGNED: Among 120 cases with no previously diagnosed AF, 33 (27.5 %) developed POAF during hospitalization. Median NPY levels were markedly elevated in the POAF group in comparison with the sinus rhythm group (31.72 vs. 27.95, P = 0.014). Multivariable logistic regression analysis revealed age (OR = 1.135, 95%CI 1.054-1.223; P = 0.001), left atrial size (OR = 1.136, 95%CI 1.004-1.285; P = 0.043), and NPY levels in peripheral blood (OR = 1.055, 95%CI 1.002-1.111; p = 0.041) independently predicted POAF. Additionally, NPY levels were positively correlated with high-frequency (HF) (r = 0.2774, P = 0.0022) and low-frequency (LF) (r = 0.2095, P = 0.0217) components of heart rate variability.
UNASSIGNED: In summary, this study demonstrates an association between elevated NPY levels in peripheral blood before surgery and POAF occurrence.
摘要：
■术后心房颤动（POAF）被认为是心脏手术后最普遍的不规则心律。心脏自主神经系统显著影响POAF,和神经肽Y（NPY），心血管系统中丰富的神经肽，参与了这种自主调节。目前的工作旨在研究NPY与POAF在接受孤立的非体外循环冠状动脉旁路移植术的个体中的潜在关联。
■从2020年1月1日至5月31日，我们检查了连续病例，这些病例成功进行了孤立的非体外循环冠状动脉旁路移植术，没有先前诊断为房颤（AF）。术前收集临床特征和血浆样本。通过酶联免疫吸附试验（ELISA）对外周血中的NPY进行定量，和POAF病例是通过7天的Holter监测确定的。
■在120例未确诊的房颤患者中，33（27.5％）在住院期间发生POAF。与窦性心律组相比，POAF组的NPY中位数水平显着升高（31.72vs.27.95,P=0.014)。多因素logistic回归分析显示年龄(OR=1.135,95CI1.054-1.223;P=0.001),左心房大小(OR=1.136,95CI1.004-1.285;P=0.043),和外周血NPY水平（OR=1.055，95CI1.002-1.111；p=0.041）独立预测了POAF。此外,NPY水平与心率变异性的高频（HF）（r=0.2774，P=0.0022）和低频（LF）（r=0.2095，P=0.0217）呈正相关。
■总之，本研究表明术前外周血NPY水平升高与POAF发生之间存在关联.
■从2020年1月1日至5月31日，我们检查了连续病例，这些病例成功进行了孤立的非体外循环冠状动脉旁路移植术，没有先前诊断为房颤（AF）。术前收集临床特征和血浆样本。通过酶联免疫吸附试验（ELISA）对外周血中的NPY进行定量，和POAF病例是通过7天的Holter监测确定的。
■在120例未确诊的房颤患者中，33（27.5％）在住院期间发生POAF。与窦性心律组相比，POAF组的NPY中位数水平显着升高（31.72vs.27.95,P=0.014)。多因素logistic回归分析显示年龄(OR=1.135,95CI1.054-1.223;P=0.001),左心房大小(OR=1.136,95CI1.004-1.285;P=0.043),和外周血NPY水平（OR=1.055，95CI1.002-1.111；p=0.041）独立预测了POAF。此外,NPY水平与心率变异性的高频（HF）（r=0.2774，P=0.0022）和低频（LF）（r=0.2095，P=0.0217）呈正相关。
■总之，本研究表明术前外周血NPY水平升高与POAF发生之间存在关联.
