PDF(Pubmed)
Abstract：
Dengue fever, an arboviral illness, exhibits a broad range of symptoms, ranging from flu-like symptoms to serious hemorrhagic complications. Hemophagocytic lymphohistiocytosis (HLH) is an uncommon pathological state caused by excessive activation of the immune system, culminating in organ dysfunction. HLH can be primary or secondary, with infection being the most common cause. The association between dengue fever and dengue-induced HLH is becoming widely acknowledged as a lethal complication. We present the case of a two-year-old male child referred for the management of dengue infection. The patient\'s condition failed to ameliorate despite appropriate treatment. On further investigation, he was diagnosed with HLH. Following the initiation of steroid therapy, the patient demonstrated gradual improvement with normalization of laboratory parameters. Differentiating between HLH and severe dengue hemorrhagic fever poses a significant challenge, emphasizing the importance of prompt diagnosis for favorable outcomes. Early identification and commencement of corticosteroid therapy are imperative for successful management.
摘要：
登革热,一种虫媒病毒病,表现出广泛的症状，从流感样症状到严重的出血性并发症。噬血细胞性淋巴组织细胞增生症(HLH)是一种由免疫系统过度激活引起的少见病理状态,最终导致器官功能障碍。HLH可以是主要的或次要的，感染是最常见的原因。登革热与登革热诱导的HLH之间的关联已被广泛认为是致命的并发症。我们介绍了一名两岁男孩因登革热感染而转诊的情况。尽管进行了适当的治疗，但患者的病情仍未改善。在进一步调查中，他被诊断为HLH。开始类固醇治疗后，随着实验室参数的正常化,患者表现出逐渐改善.区分HLH和严重的登革出血热构成了重大挑战，强调及时诊断对有利结果的重要性。早期识别和开始皮质类固醇治疗对于成功治疗至关重要。
