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Abstract：
Theileria equi (T. equi) is an apicomplexan parasite that causes severe hemolytic anemia in equids. Presently, there is inadequate knowledge of the immune responses induced by T. equi in equid hosts impeding understanding of the host parasite relationship and development of potent vaccines for control of T. equi infections. The objective of this study was to evaluate the host-parasite dynamics between T. equi merozoites and infected horses by assessing cytokine expression during primary and secondary parasite exposure, and to determine whether the pattern of expression correlated with clinical indicators of disease. Our findings showed that the expression of pro-inflammatory cytokines was very low and inconsistent during both primary and secondary infection. There was also no correlation between the symptoms observed during primary infection and expression of the cytokines. This suggests that the symptoms might have occurred primarily due to hemolysis and likely not the undesirable effects of pro-inflammatory responses. However, IL-10 and TGF-β1 were highly expressed in both phases of infection, and their expression was linked to antibody production but not moderation of pro-inflammatory cytokine responses.
摘要：
Theileriaequi(T.equi）是一种尖丛寄生虫，可引起严重的溶血性贫血。目前,对同等宿主中T.equi诱导的免疫反应的了解不足，阻碍了对宿主寄生虫关系的理解和控制T.equi感染的有效疫苗的开发。这项研究的目的是通过评估初级和次级寄生虫暴露期间的细胞因子表达来评估T.equi裂殖子和受感染马之间的宿主寄生虫动力学，并确定表达模式是否与疾病的临床指标相关。我们的发现表明，在原发和继发感染期间，促炎细胞因子的表达非常低且不一致。在初次感染期间观察到的症状与细胞因子的表达之间也没有相关性。这表明症状可能主要是由于溶血而发生,并且可能不是促炎反应的不期望的作用。然而,IL-10和TGF-β1在感染的两个阶段都高表达，它们的表达与抗体产生有关，但与促炎细胞因子反应的调节无关。
