PDF(Pubmed)
Abstract：
Hemorrhoids are a common ailment that can cause significant disruptions to one\'s daily life. While some researchers have speculated about a potential link between hemorrhoid development and gut microbes, there is currently insufficient evidence to support this claim. In this study, we collected samples from 60 hemorrhoid patients and analyzed the composition and characteristics of microbiomes in hemorrhoids. PCoA results revealed distinct differences between the microbiomes of hemorrhoids, skin-originated microbiomes, and gut microbes, highlighting the complex nature of hemorrhoidal microbiomes. The distribution characteristics of Staphylococcus suggest that the skin microbiome influences the microbiome of hemorrhoids. Additionally, we observed higher levels of Prevotella in two cases of thrombosed hemorrhoids compared to non-thrombosed hemorrhoids. This finding suggests that Prevotella may play a crucial role in the development of thrombosed hemorrhoids.
摘要：
痔疮是一种常见的疾病，可导致日常生活的严重中断。虽然一些研究人员推测痔疮发育和肠道微生物之间的潜在联系，目前没有足够的证据支持这一说法。在这项研究中,我们收集了60例痔疮患者的样本，并分析了痔疮中微生物的组成和特征。PCoA结果显示痔疮微生物组之间存在明显差异，来自皮肤的微生物组，和肠道微生物，突出了痔疮微生物的复杂性质。葡萄球菌的分布特征表明皮肤微生物组影响痔疮的微生物组。此外,我们在2例血栓性痔疮患者中观察到普雷沃氏菌水平高于非血栓性痔疮。这一发现表明Prevotella可能在血栓性痔疮的发展中起着至关重要的作用。
