Abstract：
BACKGROUND: Hernia meshes are used to reduce recurrence and pain rates, but the rates are still high. This could be improved with coatings of the mesh. This scoping review aimed to provide an overview of mesh coatings used to promote healing in abdominal hernia repair and to report beneficial and unbeneficial effects.
METHODS: We included human and animal studies with abdominal hernias that were repaired with non-commercially coated meshes. We searched Pubmed, Embase, Cochrane Central, LILACS, and CNKI without language constraints.
RESULTS: Of 2933 identified studies, 58 were included: six studies had a total of 408 humans and 52 studies had 2679 animals. The median follow-up was 12 months (range 1-156), and 95% of the hernias were incisional. There were 44 different coatings which included platelet-rich plasma, mesenchymal stem cells, growth factors, vitamin E, collagen-derived products, various polysaccharides, silk proteins, chitosan, gentamycin, doxycycline, nitrofurantoin, titanium, and diamond-like carbon. Mesenchymal stem cells and platelet-rich plasma were the most researched. Mesenchymal stem cells notably reduced inflammation and foreign body reactions but did not impact other healing metrics. In contrast, platelet-rich plasma positively influenced tissue ingrowth, collagen deposition, and neovascularization and had varying effects on inflammation and foreign body reactions.
CONCLUSIONS: We identified 44 different mesh coatings and they showed varying results. Mesenchymal stem cells and platelet-rich plasma were the most studied, with the latter showing considerable promise in improving biomechanical properties in hernia repair. Further investigations are needed to ascertain their definitive use in humans.
METHODS: We included human and animal studies with abdominal hernias that were repaired with non-commercially coated meshes. We searched Pubmed, Embase, Cochrane Central, LILACS, and CNKI without language constraints.
RESULTS: Of 2933 identified studies, 58 were included: six studies had a total of 408 humans and 52 studies had 2679 animals. The median follow-up was 12 months (range 1-156), and 95% of the hernias were incisional. There were 44 different coatings which included platelet-rich plasma, mesenchymal stem cells, growth factors, vitamin E, collagen-derived products, various polysaccharides, silk proteins, chitosan, gentamycin, doxycycline, nitrofurantoin, titanium, and diamond-like carbon. Mesenchymal stem cells and platelet-rich plasma were the most researched. Mesenchymal stem cells notably reduced inflammation and foreign body reactions but did not impact other healing metrics. In contrast, platelet-rich plasma positively influenced tissue ingrowth, collagen deposition, and neovascularization and had varying effects on inflammation and foreign body reactions.
CONCLUSIONS: We identified 44 different mesh coatings and they showed varying results. Mesenchymal stem cells and platelet-rich plasma were the most studied, with the latter showing considerable promise in improving biomechanical properties in hernia repair. Further investigations are needed to ascertain their definitive use in humans.
摘要：
背景：疝网用于减少复发率和疼痛率，但是利率仍然很高。这可以用网的涂层来改进。本范围审查旨在概述用于促进腹部疝修补术愈合的网状涂层，并报告有益和不利的效果。
方法：我们包括用非商业涂层网状物修复的腹部疝的人类和动物研究。我们搜索了Pubmed,Embase,CochraneCentral,LILACS,和CNKI没有语言约束。
结果：在2933项确定的研究中，包括58项研究：6项研究共有408人，52项研究有2679只动物。中位随访时间为12个月（范围1-156），95%的疝是切口性的.有44种不同的涂层，包括富含血小板的血浆，间充质干细胞,生长因子，维生素E,胶原蛋白衍生产品，各种多糖，丝蛋白,壳聚糖,庆大霉素,多西环素,呋喃妥因,钛，和类金刚石碳。研究最多的是间充质干细胞和富血小板血浆。间充质干细胞显著减少炎症和异物反应，但不影响其他愈合指标。相比之下,富含血小板的血浆积极影响组织向内生长，胶原蛋白沉积，和新生血管形成，对炎症和异物反应有不同的影响。
结论：我们确定了44种不同的网眼涂层，它们显示出不同的结果。间充质干细胞和富含血小板的血浆是研究最多的，后者在改善疝修复的生物力学特性方面显示出相当大的希望。需要进一步调查以确定它们在人类中的最终用途。
方法：我们包括用非商业涂层网状物修复的腹部疝的人类和动物研究。我们搜索了Pubmed,Embase,CochraneCentral,LILACS,和CNKI没有语言约束。
结果：在2933项确定的研究中，包括58项研究：6项研究共有408人，52项研究有2679只动物。中位随访时间为12个月（范围1-156），95%的疝是切口性的.有44种不同的涂层，包括富含血小板的血浆，间充质干细胞,生长因子，维生素E,胶原蛋白衍生产品，各种多糖，丝蛋白,壳聚糖,庆大霉素,多西环素,呋喃妥因,钛，和类金刚石碳。研究最多的是间充质干细胞和富血小板血浆。间充质干细胞显著减少炎症和异物反应，但不影响其他愈合指标。相比之下,富含血小板的血浆积极影响组织向内生长，胶原蛋白沉积，和新生血管形成，对炎症和异物反应有不同的影响。
结论：我们确定了44种不同的网眼涂层，它们显示出不同的结果。间充质干细胞和富含血小板的血浆是研究最多的，后者在改善疝修复的生物力学特性方面显示出相当大的希望。需要进一步调查以确定它们在人类中的最终用途。
