PDF(Pubmed)
Abstract：
A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a significant impact on a cell\'s life cycle, differentiation, proliferation, growth, regeneration, and, consequently, on the normal functioning of an entire organ. Hippo signaling and YAP/TAZ nucleocytoplasmic shuttling play a pivotal role in normal development, homeostasis, and tissue regeneration, particularly in lung cells. Intersignaling communication has a significant impact on the core components of the Hippo pathway and on YAP/TAZ localization. This review describes the crosstalk between Hippo signaling and key lung signaling pathways (WNT, SHH, TGFβ, Notch, Rho, and mTOR) using lung cells as an example and highlights the remaining unanswered questions.
摘要：
细胞是一个动态系统，其中各种过程同时发生。特别是,细胞内和细胞间信号通路串扰对细胞的生命周期有显著影响，分化,扩散,增长,再生,and,因此,整个器官的正常功能。Hippo信号和YAP/TAZ核质穿梭在正常发育中起关键作用，稳态，和组织再生，特别是在肺细胞中。信号间通信对Hippo通路的核心组成部分和YAP/TAZ定位有重大影响。这篇综述描述了Hippo信号与关键肺信号通路之间的串扰(WNT，SHH,TGFβ,缺口,Rho,和mTOR）以肺细胞为例，并突出显示其余未回答的问题。
