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Abstract：
BACKGROUND: Accumulating neuroimaging evidence indicates that patients with cervical dystonia (CD) have changes in the cortico-subcortical white matter (WM) bundle. However, whether these patients\' WM structural networks undergo reorganization remains largely unclear. We aimed to investigate topological changes in large-scale WM structural networks in patients with CD compared to healthy controls (HCs), and explore the network changes associated with clinical manifestations.
METHODS: Diffusion tensor imaging (DTI) was conducted in 30 patients with CD and 30 HCs, and WM network construction was based on the BNA-246 atlas and deterministic tractography. Based on the graph theoretical analysis, global and local topological properties were calculated and compared between patients with CD and HCs. Then, the AAL-90 atlas was used for the reproducibility analyses. In addition, the relationship between abnormal topological properties and clinical characteristics was analyzed.
RESULTS: Compared with HCs, patients with CD showed changes in network segregation and resilience, characterized by increased local efficiency and assortativity, respectively. In addition, a significant decrease of network strength was also found in patients with CD relative to HCs. Validation analyses using the AAL-90 atlas similarly showed increased assortativity and network strength in patients with CD. No significant correlations were found between altered network properties and clinical characteristics in patients with CD.
CONCLUSIONS: Our findings show that reorganization of the large-scale WM structural network exists in patients with CD. However, this reorganization is attributed to dystonia-specific abnormalities or hyperkinetic movements that need further identification.
METHODS: Diffusion tensor imaging (DTI) was conducted in 30 patients with CD and 30 HCs, and WM network construction was based on the BNA-246 atlas and deterministic tractography. Based on the graph theoretical analysis, global and local topological properties were calculated and compared between patients with CD and HCs. Then, the AAL-90 atlas was used for the reproducibility analyses. In addition, the relationship between abnormal topological properties and clinical characteristics was analyzed.
RESULTS: Compared with HCs, patients with CD showed changes in network segregation and resilience, characterized by increased local efficiency and assortativity, respectively. In addition, a significant decrease of network strength was also found in patients with CD relative to HCs. Validation analyses using the AAL-90 atlas similarly showed increased assortativity and network strength in patients with CD. No significant correlations were found between altered network properties and clinical characteristics in patients with CD.
CONCLUSIONS: Our findings show that reorganization of the large-scale WM structural network exists in patients with CD. However, this reorganization is attributed to dystonia-specific abnormalities or hyperkinetic movements that need further identification.
摘要：
背景：累积的神经影像学证据表明，宫颈肌张力障碍（CD）患者的皮质-皮质下白质（WM）束发生变化。然而,这些患者的WM结构网络是否发生重组仍不清楚。我们旨在调查与健康对照（HCs）相比，CD患者的大规模WM结构网络的拓扑变化，并探讨与临床表现相关的网络变化。
方法：对30例CD和30例HCs患者进行扩散张量成像（DTI），WM网络构建基于BNA-246图集和确定性纤维束成像。基于图的理论分析,计算并比较CD和HC患者的全局和局部拓扑特性.然后，AAL-90图集用于重现性分析.此外,分析异常拓扑性质与临床特征的关系。
结果：与HC相比，CD患者表现出网络隔离和弹性的变化，以提高本地效率和多样性为特征，分别。此外,与HC相比,CD患者的网络强度也显著下降.使用AAL-90图集进行的验证分析类似地显示，CD患者的分类能力和网络强度增加。CD患者的网络特性改变与临床特征之间没有发现显着相关性。
结论：我们的研究结果表明，CD患者存在大规模WM结构网络的重组。然而,这种重组归因于肌张力障碍特异性异常或运动过度,需要进一步鉴定.
方法：对30例CD和30例HCs患者进行扩散张量成像（DTI），WM网络构建基于BNA-246图集和确定性纤维束成像。基于图的理论分析,计算并比较CD和HC患者的全局和局部拓扑特性.然后，AAL-90图集用于重现性分析.此外,分析异常拓扑性质与临床特征的关系。
结果：与HC相比，CD患者表现出网络隔离和弹性的变化，以提高本地效率和多样性为特征，分别。此外,与HC相比,CD患者的网络强度也显著下降.使用AAL-90图集进行的验证分析类似地显示，CD患者的分类能力和网络强度增加。CD患者的网络特性改变与临床特征之间没有发现显着相关性。
结论：我们的研究结果表明，CD患者存在大规模WM结构网络的重组。然而,这种重组归因于肌张力障碍特异性异常或运动过度,需要进一步鉴定.
