NG2 胶质细胞通过抑制小胶质细胞至神经元前列腺素 E2 信号传导来防止朊病毒神经毒性。
Mesh : Animals Microglia / metabolism Dinoprostone / metabolism Mice Signal Transduction / physiology Neurons / metabolism drug effects pathology Neuroglia / metabolism Prion Diseases / metabolism pathology Mice, Inbred C57BL Antigens / metabolism Proteoglycans / metabolism Receptors, Prostaglandin E, EP4 Subtype / metabolism Prions / metabolism toxicity Cerebellum / metabolism pathology
来 源:
DOI:10.1038/s41593-024-01663-x
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