METHODS: The authors reviewed archival histiocytic tumors at their institute and found a pediatric case of ALK-H localized in a cerebellar hemisphere that had previously been reported as histiocytic sarcoma. Chemotherapy (approximately 1 year), additional surgery, and conventional chemotherapy (approximately 2.5 years) led to clinical remission, and maintenance chemotherapy was continued (approximately 1.5 years). Three years after completing treatment, a high-grade glioma was found in a cerebral hemisphere, and the patient died of the glioma 2 years later.
CONCLUSIONS: Although the prognosis of ALK-H is generally good according to prior cases, the authors\' case required long-term conventional chemotherapy, suggesting the tumor displayed aggressive characteristics. Early administration of ALK inhibitors may be necessary.
方法:作者回顾了他们研究所的存档组织细胞肿瘤,发现了一例位于小脑半球的ALK-H患儿病例,以前曾报道过这种病例为组织细胞肉瘤。化疗(约1年),额外的手术,和常规化疗(大约2.5年)导致临床缓解,并继续维持化疗(约1.5年).完成治疗三年后,在大脑半球发现了一个高级别神经胶质瘤,2年后患者死于胶质瘤.
结论:尽管根据以前的病例,ALK-H的预后通常良好,作者\'病例需要长期常规化疗,提示肿瘤表现出侵袭性特征。ALK抑制剂的早期给药可能是必要的。