Abstract：
Corynebacterium striatum is an emerging nosocomial pathogen. This is the first report showing the presence of three distinct multidrug resistant lineages of C. striatum among patients in a UK hospital. The presence of ErmX, Tet(W), Bla and AmpC proteins, and mutations in gyrA gene are associated with the resistance to clindamycin, doxycycline, penicillin and moxifloxacin, respectively. These strains are equipped with several corynebacterial virulence genes including two SpaDEF-type and a novel pilus gene cluster, which needs further molecular characterisation. This study highlights a need of developing an active surveillance strategy for routine monitoring and preventing potential cross-transmission among susceptible patients.
摘要：
纹状体棒状杆菌是一种新兴的医院病原体。这是第一份报告，显示英国一家医院的患者中存在三种不同的纹状体梭菌多药耐药谱系。ErmX的存在,Tet(W),Bla和AmpC蛋白，gyrA基因的突变与克林霉素的耐药性有关，多西环素,青霉素和莫西沙星，分别。这些菌株配备了几个棒状杆菌毒力基因，包括两个SpaDEF型和一个新的菌毛基因簇，这需要进一步的分子表征。这项研究强调需要制定积极的监测策略，以进行常规监测并防止易感患者之间的潜在交叉传播。
