Abstract：
OBJECTIVE: To describe the clinical characteristics and factors associated with disease severity in a Norwegian cohort of hospitalized patients with tick-borne encephalitis (TBE).
METHODS: This observational multicenter study included hospitalized patients with TBE in the endemic area in the southeastern region of Norway from 2018 to 2022. Clinical signs and findings from laboratory tests, EEG, CT and MRI scans were recorded. Patient characteristics were compared among those with mild, moderate, and severe TBE, and factors associated with disease severity were identified.
RESULTS: Nearly all eligible patients were included in the final cohort (153/189 participants, 81%). The median age was 56 years, 63% were men, and 7% were vaccinated against TBE; no participants were fully vaccinated. TBE presented as mild (meningeal) disease in 31% of patients and as moderate or severe (encephalitic) disease in 54% and 14% of patients, respectively. We found that 46% of the patients had a monophasic course, 64% had hyponatremia, and 7% presented with central nervous system (CNS) symptoms without pleocytosis in cerebrospinal fluid (CSF). Dysesthesia, a symptom previously not described, was reported in 10% of the patients. Most objective findings were related to the CNS. Preexisting comorbidities, CRP and CSF protein levels were predictors of more severe disease.
CONCLUSIONS: This novel presentation of a large Norwegian cohort supports TBE as a serious disease in the southeastern region of Norway. The majority of hospitalized patients presented with encephalitis, and fewer presented with meningitis. Comorbidities, CRP and CSF protein levels were associated with more severe disease.
BACKGROUND: Prosjekt #2,296,959 - The Norwegian Tick-borne Encephalitis Study - NOTES. Acute phase characteristics and long-term outcomes. - Cristin.
METHODS: This observational multicenter study included hospitalized patients with TBE in the endemic area in the southeastern region of Norway from 2018 to 2022. Clinical signs and findings from laboratory tests, EEG, CT and MRI scans were recorded. Patient characteristics were compared among those with mild, moderate, and severe TBE, and factors associated with disease severity were identified.
RESULTS: Nearly all eligible patients were included in the final cohort (153/189 participants, 81%). The median age was 56 years, 63% were men, and 7% were vaccinated against TBE; no participants were fully vaccinated. TBE presented as mild (meningeal) disease in 31% of patients and as moderate or severe (encephalitic) disease in 54% and 14% of patients, respectively. We found that 46% of the patients had a monophasic course, 64% had hyponatremia, and 7% presented with central nervous system (CNS) symptoms without pleocytosis in cerebrospinal fluid (CSF). Dysesthesia, a symptom previously not described, was reported in 10% of the patients. Most objective findings were related to the CNS. Preexisting comorbidities, CRP and CSF protein levels were predictors of more severe disease.
CONCLUSIONS: This novel presentation of a large Norwegian cohort supports TBE as a serious disease in the southeastern region of Norway. The majority of hospitalized patients presented with encephalitis, and fewer presented with meningitis. Comorbidities, CRP and CSF protein levels were associated with more severe disease.
BACKGROUND: Prosjekt #2,296,959 - The Norwegian Tick-borne Encephalitis Study - NOTES. Acute phase characteristics and long-term outcomes. - Cristin.
摘要：
目的：描述挪威蜱传脑炎（TBE）住院患者队列的临床特征和与疾病严重程度相关的因素。
方法：这项观察性多中心研究纳入了2018年至2022年挪威东南部流行地区的TBE住院患者。临床症状和实验室检查的结果，脑电图,记录CT和MRI扫描。比较轻度患者的患者特征，中度,和严重的TBE，并确定了与疾病严重程度相关的因素。
结果：几乎所有符合条件的患者都被纳入最终队列（153/189名参与者，81%)。中位年龄为56岁,63%是男性,7%的人接种了TBE疫苗;没有参与者完全接种疫苗。TBE在31％的患者中表现为轻度（脑膜）疾病，在54％和14％的患者中表现为中度或重度（脑炎）疾病，分别。我们发现46%的患者有单相病程，64%有低钠血症,7％出现中枢神经系统（CNS）症状，而脑脊液（CSF）中无细胞增多症。感觉异常,以前没有描述的症状，在10％的患者中报告。大多数客观发现与中枢神经系统有关。先前存在的合并症，CRP和CSF蛋白水平是更严重疾病的预测因子。
结论：挪威大型队列的这一新颖介绍支持TBE作为挪威东南部地区的一种严重疾病。大多数住院患者出现脑炎，很少出现脑膜炎。合并症,CRP和CSF蛋白水平与更严重的疾病有关。
背景：Prosjekt#2,296,959-挪威蜱传脑炎研究-NOTES。急性期特征和长期结果。-克里斯汀.
方法：这项观察性多中心研究纳入了2018年至2022年挪威东南部流行地区的TBE住院患者。临床症状和实验室检查的结果，脑电图,记录CT和MRI扫描。比较轻度患者的患者特征，中度,和严重的TBE，并确定了与疾病严重程度相关的因素。
结果：几乎所有符合条件的患者都被纳入最终队列（153/189名参与者，81%)。中位年龄为56岁,63%是男性,7%的人接种了TBE疫苗;没有参与者完全接种疫苗。TBE在31％的患者中表现为轻度（脑膜）疾病，在54％和14％的患者中表现为中度或重度（脑炎）疾病，分别。我们发现46%的患者有单相病程，64%有低钠血症,7％出现中枢神经系统（CNS）症状，而脑脊液（CSF）中无细胞增多症。感觉异常,以前没有描述的症状，在10％的患者中报告。大多数客观发现与中枢神经系统有关。先前存在的合并症，CRP和CSF蛋白水平是更严重疾病的预测因子。
结论：挪威大型队列的这一新颖介绍支持TBE作为挪威东南部地区的一种严重疾病。大多数住院患者出现脑炎，很少出现脑膜炎。合并症,CRP和CSF蛋白水平与更严重的疾病有关。
背景：Prosjekt#2,296,959-挪威蜱传脑炎研究-NOTES。急性期特征和长期结果。-克里斯汀.
