Abstract：
OBJECTIVE: Late follicular premature progesterone rise is a complex phenomenon encountered during assisted reproductive technology (ART) treatments; different etiologies can occur in the same patient. Low ovarian responders may be the best example, since higher FSH doses and ovarian aging-related changes may interact and generate a premature progesterone rise. This study aims to explore the correlation between progesterone levels on hCG day and the progesterone-to-follicle index and compare the progesterone-to-follicle index according to ovarian response.
METHODS: We performed a retrospective, observational, analytic, cross-sectional, and cohort study at the Reproductive Endocrinology Department at Centro Médico Nacional 20 de November between January 2015 to January 2020. After verifying for normalcy, a Spearman Rho, Principal Component Analysis, and a simple linear regression model were performed. Treatment cycles were classified according to their ovarian response. Low-ovarian responders were classified according to the Bologna Criteria. Then an ANOVA test was performed to compare each group.
RESULTS: Our results show that the progesterone-to-follicle index correlates best with progesterone levels on hCG day. Comparing all the ovarian responses, low ovarian responders have the highest progesterone-to-follicle index of the four groups.
CONCLUSIONS: Low ovarian responders produce more progesterone per follicle than regular and high responders.
METHODS: We performed a retrospective, observational, analytic, cross-sectional, and cohort study at the Reproductive Endocrinology Department at Centro Médico Nacional 20 de November between January 2015 to January 2020. After verifying for normalcy, a Spearman Rho, Principal Component Analysis, and a simple linear regression model were performed. Treatment cycles were classified according to their ovarian response. Low-ovarian responders were classified according to the Bologna Criteria. Then an ANOVA test was performed to compare each group.
RESULTS: Our results show that the progesterone-to-follicle index correlates best with progesterone levels on hCG day. Comparing all the ovarian responses, low ovarian responders have the highest progesterone-to-follicle index of the four groups.
CONCLUSIONS: Low ovarian responders produce more progesterone per follicle than regular and high responders.
摘要：
目的：晚期卵泡性早熟孕酮升高是辅助生殖技术（ART）治疗过程中遇到的复杂现象；同一患者可能发生不同的病因。低卵巢反应者可能是最好的例子，因为较高的FSH剂量和卵巢衰老相关的变化可能相互作用并导致孕酮过早升高。本研究旨在探讨hCG日孕酮水平与孕酮-卵泡指数之间的相关性，并根据卵巢反应比较孕酮-卵泡指数。
方法：我们进行了回顾性研究，观察,分析，横截面,2015年1月至2020年1月20日在国家医学中心生殖内分泌科进行队列研究。在验证是否正常之后,aSpearmanRho,主成分分析，并建立简单的线性回归模型。根据卵巢反应对治疗周期进行分类。根据博洛尼亚标准对低卵巢反应者进行分类。然后进行ANOVA测试以比较每组。
结果：我们的结果表明，在hCG日，孕酮对卵泡指数与孕酮水平的相关性最好。比较所有的卵巢反应，在四组中,低卵巢反应者的孕酮-卵泡指数最高.
结论：低卵巢反应者比正常和高反应者每个卵泡产生更多的孕酮。
方法：我们进行了回顾性研究，观察,分析，横截面,2015年1月至2020年1月20日在国家医学中心生殖内分泌科进行队列研究。在验证是否正常之后,aSpearmanRho,主成分分析，并建立简单的线性回归模型。根据卵巢反应对治疗周期进行分类。根据博洛尼亚标准对低卵巢反应者进行分类。然后进行ANOVA测试以比较每组。
结果：我们的结果表明，在hCG日，孕酮对卵泡指数与孕酮水平的相关性最好。比较所有的卵巢反应，在四组中,低卵巢反应者的孕酮-卵泡指数最高.
结论：低卵巢反应者比正常和高反应者每个卵泡产生更多的孕酮。
