PDF(Pubmed)
Abstract：
UNASSIGNED: Keloids are less responsive to any single treatment modality; hence, there is a need for combination therapy that can yield satisfactory outcomes.
UNASSIGNED: The present study assessed efficacy and safety of combination therapy-surgical excision or cryotherapy and intralesional corticosteroids along with 5-fluorouracil [IL (S + 5-FU)] injection, followed by silicone gel sheet (SGS) under compression therapy in the treatment of keloids.
UNASSIGNED: This was a retrospective, observational study comprising 21 clinically diagnosed keloid patients. All patients were treated with the stated combination therapy. Data about demographic, lesions, procedural characteristics, and treatment outcomes were reported.
UNASSIGNED: Of 21, 11 (52.4%) patients were treated with liquid nitrogen (LN2) cryotherapy, and 10 (47.6%) patients were treated with surgical excision. Mean age was 30.8 ± 7.6 (range: 14-44) years with slight male (52.4%) predominance. A mean surface area of keloid lesion was 96.8 ± 170.5 cm3. The most frequently involved site was auricle (8 [38.1%] patients). Patients received the following types of treatments: intralesional LN2 cryotherapy (6 [28.6%]), intralesional excisional surgery (6 [28.6%]), surface LN2 cryotherapy (5 [23.8%]), and extralesional excisional surgery (4 [19.0%]). Complications of recurrence (2 [9.5%]), secondary infections (2 [9.5%]), persistent postinflammatory hypopigmentation (1 [4.8%]), and atrophic scarring with postinflammatory hyperpigmentation (1 [4.8%]) were reported. After a study period of 2.5 years, 100% cure rate was achieved.
UNASSIGNED: Combination therapy of surgical excision or cryotherapy and IL (S + 5-FU), followed by SGS under compression, was safe and effective in treating keloids.
UNASSIGNED: The present study assessed efficacy and safety of combination therapy-surgical excision or cryotherapy and intralesional corticosteroids along with 5-fluorouracil [IL (S + 5-FU)] injection, followed by silicone gel sheet (SGS) under compression therapy in the treatment of keloids.
UNASSIGNED: This was a retrospective, observational study comprising 21 clinically diagnosed keloid patients. All patients were treated with the stated combination therapy. Data about demographic, lesions, procedural characteristics, and treatment outcomes were reported.
UNASSIGNED: Of 21, 11 (52.4%) patients were treated with liquid nitrogen (LN2) cryotherapy, and 10 (47.6%) patients were treated with surgical excision. Mean age was 30.8 ± 7.6 (range: 14-44) years with slight male (52.4%) predominance. A mean surface area of keloid lesion was 96.8 ± 170.5 cm3. The most frequently involved site was auricle (8 [38.1%] patients). Patients received the following types of treatments: intralesional LN2 cryotherapy (6 [28.6%]), intralesional excisional surgery (6 [28.6%]), surface LN2 cryotherapy (5 [23.8%]), and extralesional excisional surgery (4 [19.0%]). Complications of recurrence (2 [9.5%]), secondary infections (2 [9.5%]), persistent postinflammatory hypopigmentation (1 [4.8%]), and atrophic scarring with postinflammatory hyperpigmentation (1 [4.8%]) were reported. After a study period of 2.5 years, 100% cure rate was achieved.
UNASSIGNED: Combination therapy of surgical excision or cryotherapy and IL (S + 5-FU), followed by SGS under compression, was safe and effective in treating keloids.
摘要：
■瘢痕疙瘩对任何单一治疗方式的反应较弱；因此，需要能够产生满意结果的联合治疗.
■本研究评估了联合治疗-手术切除或冷冻治疗和病灶内皮质类固醇以及5-氟尿嘧啶[IL（S5-FU）]注射的疗效和安全性，其次是硅凝胶片（SGS）下加压治疗瘢痕疙瘩。
■这是一个回顾，观察性研究包括21例临床诊断的瘢痕疙瘩患者。所有患者均接受所述联合治疗。有关人口统计的数据，病变,程序特征，并报告治疗结果.
■21，11（52.4%）患者接受了液氮（LN2）冷冻治疗，10例（47.6％）患者接受了手术切除治疗。平均年龄为30.8±7.6（范围：14-44）岁，男性占主导地位（52.4％）。瘢痕疙瘩的平均表面积为96.8±170.5cm3。最常累及的部位是耳廓（8例[38.1%]）。患者接受以下类型的治疗：病灶内LN2冷冻疗法（6[28.6%]），病灶内切除手术（6[28.6%]），表面LN2冷冻疗法（5[23.8%]），和病灶外切除手术（4[19.0%]）。复发并发症（2[9.5%]），继发感染（2[9.5%]），持续的炎症后色素减退（1[4.8%]），和萎缩性瘢痕伴炎症后色素沉着过度(1[4.8%])。经过2.5年的研究，达到100%的治愈率。
■手术切除或冷冻疗法与IL(S+5-FU)联合治疗,其次是SGS压缩，治疗瘢痕疙瘩安全有效。
■本研究评估了联合治疗-手术切除或冷冻治疗和病灶内皮质类固醇以及5-氟尿嘧啶[IL（S5-FU）]注射的疗效和安全性，其次是硅凝胶片（SGS）下加压治疗瘢痕疙瘩。
■这是一个回顾，观察性研究包括21例临床诊断的瘢痕疙瘩患者。所有患者均接受所述联合治疗。有关人口统计的数据，病变,程序特征，并报告治疗结果.
■21，11（52.4%）患者接受了液氮（LN2）冷冻治疗，10例（47.6％）患者接受了手术切除治疗。平均年龄为30.8±7.6（范围：14-44）岁，男性占主导地位（52.4％）。瘢痕疙瘩的平均表面积为96.8±170.5cm3。最常累及的部位是耳廓（8例[38.1%]）。患者接受以下类型的治疗：病灶内LN2冷冻疗法（6[28.6%]），病灶内切除手术（6[28.6%]），表面LN2冷冻疗法（5[23.8%]），和病灶外切除手术（4[19.0%]）。复发并发症（2[9.5%]），继发感染（2[9.5%]），持续的炎症后色素减退（1[4.8%]），和萎缩性瘢痕伴炎症后色素沉着过度(1[4.8%])。经过2.5年的研究，达到100%的治愈率。
■手术切除或冷冻疗法与IL(S+5-FU)联合治疗,其次是SGS压缩，治疗瘢痕疙瘩安全有效。
