PDF(Pubmed)
Abstract：
UNASSIGNED: Acanthosis Nigricans (AN) is an acquired disorder of keratinization. It presents as hyperpigmentation, velvety texture of skin that can involve any part of the body including the face. Different topical, systemic therapies, or physical therapies including laser have been explored. However, there are not many randomized controlled studies for the majority of therapy alternatives besides lifestyle modifications and weight reduction.
UNASSIGNED: The aim of this study was to compare the effectiveness of 15% trichloroacetic acid (TCA) and 35% glycolic acid (GA) peel for AN.
UNASSIGNED: Forty participants were included and randomized into two groups. In groups A and B, peeling with 15% TCA and 35% GA was done, respectively. The effectiveness of each peel was assessed using changes in the Acanthosis Nigricans Area and Severity Index Score (ANASI) and Physician Assessment Score. Statistical analysis included Wilcoxon-Mann-Whitney test, Friedman test, and generalized estimating equations.
UNASSIGNED: The overall change in ANASI over time was compared in the two groups using the generalized estimating equations method. A significant difference was observed in the trend of ANASI over time between the two groups (P < 0.001). TCA peel group showed more change in ANASI as compared with GA peel group.
UNASSIGNED: In our research, 15% TCA has a better efficacy when compared with 35% GA peel after three sessions of chemical peeling. We therefore recommend the use of 15% TCA peel in AN as a safe and effective treatment option. However, more comprehensive randomized control studies are required for supporting data.
UNASSIGNED: The aim of this study was to compare the effectiveness of 15% trichloroacetic acid (TCA) and 35% glycolic acid (GA) peel for AN.
UNASSIGNED: Forty participants were included and randomized into two groups. In groups A and B, peeling with 15% TCA and 35% GA was done, respectively. The effectiveness of each peel was assessed using changes in the Acanthosis Nigricans Area and Severity Index Score (ANASI) and Physician Assessment Score. Statistical analysis included Wilcoxon-Mann-Whitney test, Friedman test, and generalized estimating equations.
UNASSIGNED: The overall change in ANASI over time was compared in the two groups using the generalized estimating equations method. A significant difference was observed in the trend of ANASI over time between the two groups (P < 0.001). TCA peel group showed more change in ANASI as compared with GA peel group.
UNASSIGNED: In our research, 15% TCA has a better efficacy when compared with 35% GA peel after three sessions of chemical peeling. We therefore recommend the use of 15% TCA peel in AN as a safe and effective treatment option. However, more comprehensive randomized control studies are required for supporting data.
摘要：
■黑棘皮病（AN）是一种获得性角质化疾病。它表现为色素沉着过度，天鹅绒般的皮肤纹理，可以涉及身体的任何部位，包括面部。不同的局部，全身疗法,或物理治疗，包括激光已经探索。然而,除了改变生活方式和减轻体重外，大多数治疗方案的随机对照研究并不多。
■本研究的目的是比较15％三氯乙酸（TCA）和35％乙醇酸（GA）果皮对AN的有效性。
■40名参与者被随机分为两组。在A组和B组中，用15%TCA和35%GA进行剥离，分别。使用黑棘皮病面积和严重程度指数评分（ANASI）和医师评估评分的变化评估每种果皮的有效性。统计分析包括Wilcoxon-Mann-Whitney检验，弗里德曼测试,和广义估计方程。
■使用广义估计方程方法在两组中比较了ANASI随时间的总体变化。两组间ANASI随时间变化的趋势有显著差异(P<0.001)。与GA剥离组相比，TCA剥离组的ANASI变化更大。
■在我们的研究中，在化学剥离三次后,与35%GA剥离相比,15%TCA具有更好的功效。因此，我们建议在AN中使用15％的TCA果皮作为安全有效的治疗选择。然而,需要更全面的随机对照研究来支持数据。
■本研究的目的是比较15％三氯乙酸（TCA）和35％乙醇酸（GA）果皮对AN的有效性。
■40名参与者被随机分为两组。在A组和B组中，用15%TCA和35%GA进行剥离，分别。使用黑棘皮病面积和严重程度指数评分（ANASI）和医师评估评分的变化评估每种果皮的有效性。统计分析包括Wilcoxon-Mann-Whitney检验，弗里德曼测试,和广义估计方程。
■使用广义估计方程方法在两组中比较了ANASI随时间的总体变化。两组间ANASI随时间变化的趋势有显著差异(P<0.001)。与GA剥离组相比，TCA剥离组的ANASI变化更大。
■在我们的研究中，在化学剥离三次后,与35%GA剥离相比,15%TCA具有更好的功效。因此，我们建议在AN中使用15％的TCA果皮作为安全有效的治疗选择。然而,需要更全面的随机对照研究来支持数据。
