PDF(Pubmed)
Abstract：
UNASSIGNED: Ameloblastoma is one of the major odontogenic neoplasms with an invasive and recurrence potential. Its tumourigenesis and proliferative capacity can be attributed to the activation or inactivation of certain molecular signalling pathways. Hippo signalling pathway is known to regulate diverse physiological processes related to mitosis and organ growth and is an emerging tumour suppressor pathway, the dysfunction of which is implicated in various diseases including cancers. Yes-associated protein1 (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the downstream effectors in the Hippo cascade, which on nuclear activation leads to cellular proliferation in various tumours.
UNASSIGNED: The current study was undertaken to evaluate the expression of YAP in various histopathological variants of ameloblastoma and unicystic ameloblastoma.
UNASSIGNED: Fifty formalin-fixed paraffin-embedded tissue samples of histopathologically diagnosed cases of ameloblastoma, and 10 histopathologically diagnosed cases of unicystic ameloblastoma were obtained from the departmental archives to evaluate the immunohistochemical expression of YAP both manually and by software analysis.
UNASSIGNED: More than 90% of cases of conventional ameloblastoma and unicystic ameloblastoma elicited positive expression of YAP. No statistical difference was found among different histopathological variants of conventional ameloblastoma. Significant difference between the means of all four quantitative score groups was observed.
UNASSIGNED: In view of the modulating effect of YAP in tumourigenesis and its higher expression in ameloblastoma, further exploration of this molecule appears to be a promising area of research.
UNASSIGNED: The current study was undertaken to evaluate the expression of YAP in various histopathological variants of ameloblastoma and unicystic ameloblastoma.
UNASSIGNED: Fifty formalin-fixed paraffin-embedded tissue samples of histopathologically diagnosed cases of ameloblastoma, and 10 histopathologically diagnosed cases of unicystic ameloblastoma were obtained from the departmental archives to evaluate the immunohistochemical expression of YAP both manually and by software analysis.
UNASSIGNED: More than 90% of cases of conventional ameloblastoma and unicystic ameloblastoma elicited positive expression of YAP. No statistical difference was found among different histopathological variants of conventional ameloblastoma. Significant difference between the means of all four quantitative score groups was observed.
UNASSIGNED: In view of the modulating effect of YAP in tumourigenesis and its higher expression in ameloblastoma, further exploration of this molecule appears to be a promising area of research.
摘要：
■成釉细胞瘤是一种主要的牙源性肿瘤，具有侵袭性和复发潜力。其肿瘤发生和增殖能力可归因于某些分子信号通路的激活或失活。Hippo信号通路已知可调节与有丝分裂和器官生长相关的多种生理过程，是一种新兴的肿瘤抑制途径。其功能障碍与包括癌症在内的各种疾病有关。Yes相关蛋白1（YAP）和具有PDZ结合基序（TAZ）的转录共激活因子是Hippo级联中的下游效应子，核激活导致各种肿瘤的细胞增殖。
■本研究旨在评估YAP在成釉细胞瘤和单囊性成釉细胞瘤的各种组织病理学变异中的表达。
■组织病理学诊断的成釉细胞瘤病例的50个福尔马林固定石蜡包埋的组织样本，从部门档案中获得10例经组织病理学诊断的单囊性成釉细胞瘤病例，以手动和软件分析评估YAP的免疫组织化学表达。
■超过90％的常规成釉细胞瘤和单囊性成釉细胞瘤引起YAP阳性表达。在常规成釉细胞瘤的不同组织病理学变异之间没有发现统计学差异。观察到所有四个定量评分组的平均值之间的显着差异。
■鉴于YAP在肿瘤发生中的调节作用及其在成釉细胞瘤中的高表达，对该分子的进一步探索似乎是一个有希望的研究领域。
■本研究旨在评估YAP在成釉细胞瘤和单囊性成釉细胞瘤的各种组织病理学变异中的表达。
■组织病理学诊断的成釉细胞瘤病例的50个福尔马林固定石蜡包埋的组织样本，从部门档案中获得10例经组织病理学诊断的单囊性成釉细胞瘤病例，以手动和软件分析评估YAP的免疫组织化学表达。
■超过90％的常规成釉细胞瘤和单囊性成釉细胞瘤引起YAP阳性表达。在常规成釉细胞瘤的不同组织病理学变异之间没有发现统计学差异。观察到所有四个定量评分组的平均值之间的显着差异。
■鉴于YAP在肿瘤发生中的调节作用及其在成釉细胞瘤中的高表达，对该分子的进一步探索似乎是一个有希望的研究领域。
