PDF(Pubmed)
Abstract：
c-KIT is an important diagnostic marker in salivary gland tumours and is expressed in most adenoid cystic carcinomas. Histologically similar salivary gland tumours with variable immunohistochemical expression for c-KIT pose a challenge and make diagnostic reliability ambivalent. An electronic search was performed in MEDLINE by PubMed, Google Scholar, Scopus, Trip, Cochrane Library, and EMBASE up to 31 December 2023, without period restriction. The articles that investigated CD117 or c-KIT in salivary gland tumours were included for review. Sensitivity, specificity, and positive and negative predictive values of c-KIT immunohistochemical expressions were derived and subjected to meta-analysis using Open Meta analyst for Sierra software. The risk of bias in selected studies was analysed using the QUADAS-2 tool, and RevMan 5.4 was used to output the result. Forty-three articles were reviewed, and 2285 salivary gland cases were analysed. Adenoid cystic carcinoma had an overall expression of 84.9%. A similar expression was found in epimyoepithelial carcinoma (79.1%), lymphoepithelial carcinoma (75%), myoepithelial carcinoma (60.8%), monomorphic adenoma (94.1%), and pleomorphic adenoma (74.7%). The sensitivity, specificity, and positive and negative predictive values of c-KIT/CD117 for adenoid cystic carcinoma with other salivary gland tumours were 84.99%, 69.09%, 84.79%, and 69.41%, respectively. Current evidence shows that c-KIT, despite its sensitivity, is not specific and therefore cannot be a useful diagnostic marker for distinguishing adenoid cystic carcinoma from other salivary gland tumours. Further research on other salivary gland tumours that exhibit comparable expression is necessary to validate the diagnostic accuracy of c-KIT.
摘要：
c-KIT是唾液腺肿瘤的重要诊断标志物，在大多数腺样囊性癌中表达。组织学上相似的唾液腺肿瘤，c-KIT的免疫组织化学表达可变，这构成了挑战，并使诊断可靠性变得矛盾。PubMed在MEDLINE中进行了电子搜索，谷歌学者，Scopus,行程,科克伦图书馆,和EMBASE至2023年12月31日，无期限限制。包括研究唾液腺肿瘤中CD117或c-KIT的文章以供审查。灵敏度,特异性，得出c-KIT免疫组织化学表达的阳性和阴性预测值，并使用Sierra软件的OpenMeta分析软件进行荟萃分析。使用QUADAS-2工具分析了选定研究中的偏倚风险，并使用RevMan5.4输出结果。审查了43篇文章，分析2285例唾液腺病例。腺样囊性癌的总表达率为84.9%。在上皮上皮癌中发现了相似的表达（79.1％），淋巴上皮癌（75%），肌上皮癌（60.8%），单形性腺瘤（94.1%），多形性腺瘤（74.7%）。敏感性,特异性，c-KIT/CD117对腺样囊性癌合并其他涎腺肿瘤的阳性和阴性预测值为84.99%，69.09%,84.79%,和69.41%，分别。目前的证据表明c-KIT,尽管它很敏感,没有特异性，因此不能作为区分腺样囊性癌与其他唾液腺肿瘤的有用诊断标记。对表现出相当表达的其他唾液腺肿瘤的进一步研究对于验证c-KIT的诊断准确性是必要的。
