PDF(Pubmed)
Abstract：
UNASSIGNED: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with significant morbidity and mortality. Identifying potential premalignant lesions is crucial for early detection and effective management. Lichen planus (LP), a chronic inflammatory disorder has been associated with an increased risk of developing OSCC. This study aimed to assess the diagnostic importance of p16 and p53 expression in identifying LP as a potential premalignant lesion for OSCC.
UNASSIGNED: A retrospective analysis was conducted on archived tissue samples from patients diagnosed with LP (n = 80) and OSCC (n = 60) between 2017 and 2022. Immunohistochemistry was performed to evaluate p16 and p53 protein expression levels in both LP and OSCC tissues. Clinical data, including patient demographics and lesion characteristics, were collected and correlated with the immunohistochemical findings.
UNASSIGNED: The results revealed a significantly higher prevalence of p16 and p53 expression in LP tissues compared to normal oral mucosa (P < 0.001). Notably, p16 expression was observed in 70% of LP cases, while p53 was detected in 55% of LP cases. Furthermore, a significant association was established between p53 expression and the presence of dysplasia within LP lesions (P = 0.003). This indicates the potential of p53 as a predictive biomarker for malignant transformation in LP. The correlation between p16 and p53 expression levels in LP and OSCC tissues suggests a potential mechanistic link between LP and OSCC development.
UNASSIGNED: This study underscores the diagnostic importance of p16 and p53 expression as potential markers for identifying LP as a premalignant lesion in the context of OSCC. The elevated prevalence of these markers in LP tissues suggests a potential role in predicting malignant transformation. The findings contribute to a deeper understanding of the molecular pathways underlying OSCC development from LP and emphasize the need for regular monitoring and early intervention in patients diagnosed with LP. Further prospective studies are warranted to validate these findings and to explore the clinical utility of p16 and p53 as biomarkers for predicting OSCC risk in LP patients.
UNASSIGNED: A retrospective analysis was conducted on archived tissue samples from patients diagnosed with LP (n = 80) and OSCC (n = 60) between 2017 and 2022. Immunohistochemistry was performed to evaluate p16 and p53 protein expression levels in both LP and OSCC tissues. Clinical data, including patient demographics and lesion characteristics, were collected and correlated with the immunohistochemical findings.
UNASSIGNED: The results revealed a significantly higher prevalence of p16 and p53 expression in LP tissues compared to normal oral mucosa (P < 0.001). Notably, p16 expression was observed in 70% of LP cases, while p53 was detected in 55% of LP cases. Furthermore, a significant association was established between p53 expression and the presence of dysplasia within LP lesions (P = 0.003). This indicates the potential of p53 as a predictive biomarker for malignant transformation in LP. The correlation between p16 and p53 expression levels in LP and OSCC tissues suggests a potential mechanistic link between LP and OSCC development.
UNASSIGNED: This study underscores the diagnostic importance of p16 and p53 expression as potential markers for identifying LP as a premalignant lesion in the context of OSCC. The elevated prevalence of these markers in LP tissues suggests a potential role in predicting malignant transformation. The findings contribute to a deeper understanding of the molecular pathways underlying OSCC development from LP and emphasize the need for regular monitoring and early intervention in patients diagnosed with LP. Further prospective studies are warranted to validate these findings and to explore the clinical utility of p16 and p53 as biomarkers for predicting OSCC risk in LP patients.
摘要：
■口腔鳞状细胞癌（OSCC）是一种常见的恶性肿瘤，具有显著的发病率和死亡率。识别潜在的癌前病变对于早期发现和有效管理至关重要。扁平苔藓(LP),慢性炎症性疾病与OSCC发病风险增加相关.这项研究旨在评估p16和p53表达在鉴定LP为OSCC的潜在癌前病变中的诊断重要性。
■对2017年至2022年间诊断为LP（n=80）和OSCC（n=60）的患者的存档组织样本进行了回顾性分析。进行免疫组织化学以评估LP和OSCC组织中的p16和p53蛋白表达水平。临床数据,包括患者的人口统计学和病变特征，收集并与免疫组织化学结果相关。
■结果显示，与正常口腔粘膜相比，LP组织中p16和p53表达的患病率明显更高（P<0.001）。值得注意的是,在70％的LP病例中观察到p16表达，而在55％的LP病例中检测到p53。此外，p53表达与LP病变内发育异常之间存在显著关联(P=0.003).这表明p53作为LP中恶性转化的预测生物标志物的潜力。LP和OSCC组织中p16和p53表达水平之间的相关性表明LP和OSCC发展之间的潜在机制联系。
■这项研究强调了p16和p53表达作为在OSCC背景下鉴定LP为恶变前病变的潜在标志物的诊断重要性。LP组织中这些标志物的患病率升高表明在预测恶性转化中具有潜在作用。这些发现有助于更深入地了解LPOSCC发展的分子途径，并强调需要对诊断为LP的患者进行定期监测和早期干预。需要进一步的前瞻性研究来验证这些发现，并探索p16和p53作为预测LP患者OSCC风险的生物标志物的临床实用性。
■对2017年至2022年间诊断为LP（n=80）和OSCC（n=60）的患者的存档组织样本进行了回顾性分析。进行免疫组织化学以评估LP和OSCC组织中的p16和p53蛋白表达水平。临床数据,包括患者的人口统计学和病变特征，收集并与免疫组织化学结果相关。
■结果显示，与正常口腔粘膜相比，LP组织中p16和p53表达的患病率明显更高（P<0.001）。值得注意的是,在70％的LP病例中观察到p16表达，而在55％的LP病例中检测到p53。此外，p53表达与LP病变内发育异常之间存在显著关联(P=0.003).这表明p53作为LP中恶性转化的预测生物标志物的潜力。LP和OSCC组织中p16和p53表达水平之间的相关性表明LP和OSCC发展之间的潜在机制联系。
■这项研究强调了p16和p53表达作为在OSCC背景下鉴定LP为恶变前病变的潜在标志物的诊断重要性。LP组织中这些标志物的患病率升高表明在预测恶性转化中具有潜在作用。这些发现有助于更深入地了解LPOSCC发展的分子途径，并强调需要对诊断为LP的患者进行定期监测和早期干预。需要进一步的前瞻性研究来验证这些发现，并探索p16和p53作为预测LP患者OSCC风险的生物标志物的临床实用性。
