关键词: clinical application molecular pathogenesis omics prostate cancer sequencing

来  源:   DOI:10.3389/fonc.2024.1355551   PDF(Pubmed)

Abstract:
UNASSIGNED: Prostate cancer (PCa) is one of the most threatening health problems for the elderly males. However, our understanding of the disease has been limited by the research technology for a long time. Recently, the maturity of sequencing technology and omics studies has been accelerating the studies of PCa, establishing themselves as an essential impetus in this field.
UNASSIGNED: We assessed Web of Science (WoS) database for publications of sequencing and omics studies in PCa on July 3rd, 2023. Bibliometrix was used to conduct ulterior bibliometric analysis of countries/affiliations, authors, sources, publications, and keywords. Subsequently, purposeful large amounts of literature reading were proceeded to analyze research hotspots in this field.
UNASSIGNED: 3325 publications were included in the study. Research associated with sequencing and omics studies in PCa had shown an obvious increase recently. The USA and China were the most productive countries, and harbored close collaboration. CHINNAIYAN AM was identified as the most influential author, and CANCER RESEARCH exhibited huge impact in this field. Highly cited publications and their co-citation relationships were used to filtrate literatures for subsequent literature reading. Based on keyword analysis and large amounts of literature reading, \'the molecular pathogenesis of PCa\' and \'the clinical application of sequencing and omics studies in PCa\' were summarized as two research hotspots in the field.
UNASSIGNED: Sequencing technology had a deep impact on the studies of PCa. Sequencing and omics studies in PCa helped researchers reveal the molecular pathogenesis, and provided new possibilities for the clinical practice of PCa.
摘要:
前列腺癌(PCa)是老年男性最具威胁性的健康问题之一。然而,长期以来,我们对这种疾病的认识一直受到研究技术的限制。最近,测序技术和组学研究的成熟加速了PCa的研究,将自己确立为这一领域的重要推动力。
我们于7月3日评估了WebofScience(WoS)数据库中有关PCa测序和组学研究的出版物,2023年。Bibliometrix用于对国家/隶属关系进行前瞻性文献计量分析,作者,来源,出版物,和关键词。随后,进行了有目的的大量文献阅读,分析了该领域的研究热点。
3325出版物被纳入研究。与PCa的测序和组学研究相关的研究最近显示出明显增加。美国和中国是生产力最高的国家,并紧密合作。CHINNAIYANAM被确定为最具影响力的作者,和癌症研究在这一领域表现出巨大的影响。高度引用的出版物及其共同引用关系用于过滤文献以供后续文献阅读。在关键词分析和大量文献阅读的基础上,“PCa的分子发病机制”和“测序和组学研究在PCa中的临床应用”是该领域的两个研究热点。
测序技术对PCa的研究产生了深远的影响。PCa的测序和组学研究帮助研究人员揭示了分子发病机理,为PCa的临床实践提供了新的可能。
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