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Abstract：
Our article examines a rare case where hypothyroidism due to Hashimoto\'s thyroiditis progressed, after a long period (three years) of L-thyroxine substitution, into confirmed hyperthyroidism due to Graves\' disease in a 69-year-old man. The article explores possible mechanisms of this unusual transition based on our case and others reported in the literature. Findings suggest that the coexistence of Hashimoto\'s thyroiditis and Graves\' disease can lead to transitions between hypothyroidism and hyperthyroidism, influenced by the predominance of involved antibodies and residual capacity of thyroid tissue. The authors emphasize the importance of further studies to better understand these transitions and identify at-risk patients. In conclusion, the article highlights the necessity of considering the rare possibility of transition to Graves\' disease in patients presenting with persistent hyperthyroidism despite cessation of L-thyroxine.
摘要：
我们的文章检查了一个罕见的病例，其中桥本甲状腺炎导致的甲状腺功能减退进展，经过长期（三年）的L-甲状腺素替代，一名69岁男子因Graves病确诊甲状腺功能亢进。本文根据我们的案例和文献中报道的其他案例，探讨了这种异常转变的可能机制。研究结果表明桥本甲状腺炎和Graves病的共存可导致甲状腺功能减退和甲状腺功能亢进之间的转变。受累抗体占优势和甲状腺组织残余容量的影响。作者强调了进一步研究的重要性，以更好地了解这些转变并识别有风险的患者。总之,这篇文章强调,尽管停止使用L-甲状腺素,但在表现为持续性甲状腺功能亢进的患者中,必须考虑罕见的过渡到Graves病的可能性.
