PDF(Pubmed)
Abstract：
This case reports a 35-year-old man who presented with a painful erythematous nodule on his right posterior calf. He first noticed this nodule several years ago and it often bled upon contact with clothing. An excisional biopsy of the skin lesion revealed two distinct populations of cells. One population of epithelioid cells stained positive for Mart-1, HMB45, and SOX-10, confirming the diagnosis of malignant melanoma. The second population of cells stained positive for desmin and calponin, confirming the diagnosis of sarcoma with muscular differentiation. Subsequently, these unusual findings led to the diagnosis of a collision tumor comprising malignant melanoma and rhabdomyosarcoma. Follow-up PET/CT and brain MRI revealed no metastasis from the primary skin lesion. This case highlights a rare combination of cell types found within a collision tumor in addition to providing details on how to diagnose this skin lesion.
摘要：
该病例报道了一名35岁的男子，他的右小腿后部出现了疼痛的红斑结节。几年前，他第一次注意到这个结节，它经常在与衣服接触时流血。皮肤病变的切除活检显示了两个不同的细胞群。一组上皮样细胞对Mart-1，HMB45和SOX-10染色呈阳性，证实了恶性黑色素瘤的诊断。第二组细胞的结蛋白和钙蛋白染色呈阳性，确认有肌肉分化的肉瘤的诊断。随后，这些不寻常的发现导致了包括恶性黑色素瘤和横纹肌肉瘤的碰撞肿瘤的诊断。随访PET/CT和脑MRI显示原发性皮肤病变无转移。除了提供有关如何诊断这种皮肤病变的详细信息外，该病例还突出了在碰撞肿瘤中发现的罕见细胞类型组合。
