PDF(Pubmed)
Abstract：
To investigate the association of gene polymorphisms of TNF-α-308G/A rs1800629 with the susceptibility and severity of rheumatoid arthritis (RA), literature from PubMed, EMBASE, Web of Science and CNKI databases was searched. Two authors screened the literature independently, extracted data and evaluated the risk of bias of the included studies. According to the inclusion and exclusion criteria, five genetic models were established: The allelic model (A vs. G), dominant model (GA + AA vs. GG), recessive model (AA vs. GG + GA), co-dominant model (AA vs. GG) and super-dominant model (GG + AA vs. GA). Stata 17.0 software was used for the meta-analysis. A total of 34 eligible studies with 12,611 subjects were included, including 6,030 cases in the RA group and 6,581 controls. Meta-analysis calculations revealed that the genetic polymorphisms of TNF-α-308G/A rs1800629 were not significantly associated with susceptibility to RA, with an odds ratio and 95% confidence interval (CI) for each genetic model [A vs. G: 0.937 (0.762-1.152); GA + AA vs. GG: 0.918 (0.733-1.148); AA vs. GG + GA: 1.131 (0.709-1.802); AA vs. GG: 1.097 (0.664-1.813); and GG + AA vs. GA: 1.108 (0.894-1.373)]. For the association between TNF-α-308G/A rs1800629 gene polymorphisms and the severity of RA, the results of subgroup analysis calculations showed that TNF-α-308G/A rs1800629 gene polymorphisms were associated with the severity of RA in European populations, with the gene model and 95% CI [GA + AA vs. GG: 0.503 (0.297-0.853); and GG + AA vs. GA: 2.268 (1.434-3.590)]. When assessing the confidence in the positive results of the present study through the false-positive report probability, the positive results were observed to be reliable. No significant association was observed between genetic polymorphisms in TNF-α-308G/A rs1800629 and susceptibility to RA. However, a significant association exists with the severity of RA in European populations.
摘要：
探讨TNF-α-308G/Ars1800629基因多态性与类风湿关节炎(RA)易感性及严重程度的关系。PubMed的文献，EMBASE,搜索了WebofScience和CNKI数据库。两位作者独立筛选了文献，提取数据并评估纳入研究的偏倚风险。根据纳入和排除标准，建立了五个遗传模型：等位基因模型(A与G),主导模型(GA+AA与GG),隐性模型(AA与GG+GA),共同主导模型(AA与GG）和超主导模型（GG+AA与GA).采用Stata17.0软件进行Meta分析。总共纳入了34项符合条件的研究，包括12,611名受试者，包括RA组6,030例和6,581例对照。Meta分析结果显示,TNF-α-308G/Ars1800629基因多态性与RA易感性无显著相关性,每个遗传模型的比值比和95%置信区间(CI)[A与G:0.937(0.762-1.152);GA+AAvs.GG：0.918（0.733-1.148）；AAvs.GG+GA：1.131（0.709-1.802）；AAvs.GG：1.097（0.664-1.813）；GG+AAvs.GA:1.108(0.894-1.373)]。TNF-α-308G/Ars1800629基因多态性与RA严重程度的关系,亚组分析计算结果表明，TNF-α-308G/Ars1800629基因多态性与欧洲人群RA的严重程度相关，基因模型和95%CI[GA+AAvs.GG：0.503（0.297-0.853）；GG+AA与GA:2.268(1.434-3.590)].当通过假阳性报告概率评估本研究阳性结果的置信度时，观察到阳性结果是可靠的.TNF-α-308G/Ars1800629基因多态性与RA易感性无显著关联。然而,在欧洲人群中,与RA的严重程度存在显著关联.
