PDF(Pubmed)
Abstract：
The soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) superfamily plays a pivotal role in cellular trafficking by facilitating membrane fusion events. These SNARE proteins, including syntaxins, assemble into complexes that actively facilitate specific membrane fusion events. Syntaxins, as integral components of the SNARE complex, play a crucial role in initiating and regulating these fusion activities. While specific syntaxins have been extensively studied in various cellular processes, including neurotransmitter release, autophagy and endoplasmic reticulum (ER)-to-Golgi protein transport, their roles in the retina remain less explored. This review aims to enhance our understanding of syntaxins\' functions in the retina by shedding light on how syntaxins mediate membrane fusion events unique to the retina. Additionally, we seek to establish a connection between syntaxin mutations and retinal diseases. By exploring the intricate interplay of syntaxins in retinal function and health, we aim to contribute to the broader comprehension of cellular trafficking in the context of retinal physiology and pathology.
摘要：
可溶性N-乙基马来酰亚胺敏感因子（NSF）附着蛋白（SNAP）受体（SNARE）超家族通过促进膜融合事件在细胞运输中起关键作用。这些陷阱蛋白，包括语法蛋白，组装成复合物，积极促进特定的膜融合事件。Syntaxins,作为SNARE复合体的组成部分，在启动和调节这些融合活动中起着至关重要的作用。虽然已经在各种细胞过程中广泛研究了特定的突触体，包括神经递质的释放,自噬和内质网（ER）-至高尔基体蛋白转运，它们在视网膜中的作用尚不清楚.这篇综述旨在通过揭示突触素如何介导视网膜特有的膜融合事件来增强我们对视网膜中突触素功能的理解。此外,我们寻求在syntaxin突变和视网膜疾病之间建立联系。通过探索视网膜功能和健康中语法蛋白的复杂相互作用，我们的目标是有助于更广泛地理解视网膜生理学和病理学背景下的细胞运输。
