PDF(Pubmed)
Abstract：
Cerebellar ataxia is an uncommon and atypical manifestation of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, often accompanied by seizures, psychiatric symptoms, and cognitive deficits. Previous cases of isolated brainstem-cerebellar symptoms in patients with anti-NMDAR encephalitis have not been documented. This report presents a case of anti-NMDAR encephalitis in which the patient exhibited cerebellar ataxia, nystagmus, diplopia, positive bilateral pathological signs, and hemiparesthesia with no other accompanying symptoms or signs. The presence of positive CSF anti-NMDAR antibodies further supports the diagnosis. Other autoantibodies were excluded through the use of cell-based assays. Immunotherapy was subsequently administered, leading to a gradual recovery of the patient.
摘要：
小脑共济失调是抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎的罕见和非典型表现，经常伴有癫痫发作，精神症状,和认知缺陷。尚未记录抗NMDAR脑炎患者的孤立脑干-小脑症状的先前病例。本报告介绍了一例抗NMDAR脑炎，其中患者表现出小脑共济失调，眼球震颤,复视,双侧病理征象阳性,和感觉偏瘫，无其他伴随症状或体征。阳性CSF抗NMDAR抗体的存在进一步支持诊断。通过使用基于细胞的测定排除其他自身抗体。随后进行了免疫治疗，导致患者逐渐康复。
