PDF(Pubmed)
Abstract：
Globally, breast cancer stands as the most prevalent form of cancer among women. The tumor microenvironment of breast cancer often exhibits hypoxia. Hypoxia-inducible factor 1-alpha, a transcription factor, is found to be overexpressed and activated in breast cancer, playing a pivotal role in the anoxic microenvironment by mediating a series of reactions. Hypoxia-inducible factor 1-alpha is involved in regulating downstream pathways and target genes, which are crucial in hypoxic conditions, including glycolysis, angiogenesis, and metastasis. These processes significantly contribute to breast cancer progression by managing cancer-related activities linked to tumor invasion, metastasis, immune evasion, and drug resistance, resulting in poor prognosis for patients. Consequently, there is a significant interest in Hypoxia-inducible factor 1-alpha as a potential target for cancer therapy. Presently, research on drugs targeting Hypoxia-inducible factor 1-alpha is predominantly in the preclinical phase, highlighting the need for an in-depth understanding of HIF-1α and its regulatory pathway. It is anticipated that the future will see the introduction of effective HIF-1α inhibitors into clinical trials, offering new hope for breast cancer patients. Therefore, this review focuses on the structure and function of HIF-1α, its role in advancing breast cancer, and strategies to combat HIF-1α-dependent drug resistance, underlining its therapeutic potential.
摘要：
全球范围内,乳腺癌是女性中最常见的癌症。乳腺癌的肿瘤微环境常表现为缺氧。缺氧诱导因子1-α，转录因子，在乳腺癌中被过度表达和激活，通过介导一系列反应在缺氧微环境中发挥关键作用。缺氧诱导因子1-α参与调节下游通路和靶基因，这在缺氧条件下至关重要，包括糖酵解,血管生成,和转移。这些过程通过管理与肿瘤侵袭相关的癌症相关活动，显著促进乳腺癌进展。转移,免疫逃避,和抗药性，导致患者预后不良。因此,低氧诱导因子1-α作为癌症治疗的潜在靶点引起了人们的极大兴趣.目前,针对缺氧诱导因子1-α的药物研究主要处于临床前阶段，强调需要深入了解HIF-1α及其调控途径。预计未来将在临床试验中引入有效的HIF-1α抑制剂，为乳腺癌患者带来新的希望。因此,本文对HIF-1α的结构和功能进行综述,它在推进乳腺癌中的作用，以及对抗HIF-1α依赖性耐药性的策略，强调其治疗潜力。
