PDF(Pubmed)
Abstract：
The protein, Nuclear factor-E2-related factor 2 (Nrf2), is a transitory protein that acts as a transcription factor and is involved in the regulation of many cytoprotective genes linked to xenobiotic metabolism and antioxidant responses. Based on the existing clinical and experimental data, it can be inferred that neurodegenerative diseases are characterized by an excessive presence of markers of oxidative stress (OS) and a reduced presence of antioxidant defense systems in both the brain and peripheral tissues. The presence of imbalances in the homeostasis between oxidants and antioxidants has been recognized as a substantial factor in the pathogenesis of neurodegenerative disorders. The dysregulations include several cellular processes such as mitochondrial failure, protein misfolding, and neuroinflammation. These dysregulations all contribute to the disruption of proteostasis in neuronal cells, leading to their eventual mortality. A noteworthy component of Nrf2, as shown by recent research undertaken over the last decade, is to its role in the development of resistance to OS. Nrf2 plays a pivotal role in regulating systems that defend against OS. Extant research offers substantiation for the protective and defensive roles of Nrf2 in the context of neurodegenerative diseases. The purpose of this study is to provide a comprehensive analysis of the influence of Nrf2 on OS and its function in regulating antioxidant defense systems within the realm of neurodegenerative diseases. Furthermore, we evaluate the most recent academic inquiries and empirical evidence about the beneficial and potential role of certain Nrf2 activator compounds within the realm of therapeutic interventions.
摘要：
蛋白质,核因子-E2相关因子2（Nrf2），是一种作为转录因子的暂时蛋白，参与许多与异源生物代谢和抗氧化反应相关的细胞保护基因的调节。基于现有的临床和实验数据,可以推断，神经退行性疾病的特征是氧化应激（OS）标志物的过度存在和在脑和外周组织中抗氧化剂防御系统的减少。氧化剂和抗氧化剂之间的稳态失衡的存在已被认为是神经退行性疾病发病机理中的重要因素。失调包括几个细胞过程，如线粒体衰竭，蛋白质折叠错误，和神经炎症。这些失调都有助于神经元细胞中蛋白质平衡的破坏，导致他们最终死亡。Nrf2的一个值得注意的组成部分，如最近十年进行的研究所示，是对其在开发中的角色抵制OS。Nrf2在监管防御OS的系统方面发挥着关键作用。现有研究为Nrf2在神经退行性疾病中的保护和防御作用提供了依据。这项研究的目的是全面分析Nrf2对OS的影响及其在神经退行性疾病领域中调节抗氧化防御系统的功能。此外，我们评估了有关某些Nrf2激活剂化合物在治疗干预领域的有益和潜在作用的最新学术调查和经验证据.
