PDF(Pubmed)
Abstract：
Toxic agents can adversely impact the male reproductive system mainly via activating oxidative stress affecting the seminiferous epithelia, spermatogenesis, sperms, and the testis. Toxic agents lead to the excessive generation of reactive oxygen species (ROS), such as hydroxyl radicals, hydrogen peroxide, and superoxide anions. ROS exert a cytotoxic effect and oxidative damage to nucleic acids, proteins, and membrane lipids. Hesperidin is a pharmacologically active phytoflavone abundantly occurring in citrus fruits, such as oranges and lemons. It has shown various pharmacological properties such as antioxidant, anti-inflammatory, anti-carcinogenic, analgesic, antiviral, anti-coagulant, hypolipidemic, and hypoglycemic effects. Hesperidin has been found to exert protective effects against natural and chemical toxins-induced organ toxicity. Considerable evidence has implicated the testicular protective effects of hesperidin against the toxicological properties of pharmaceutical drugs as well as biological and chemical agents, and in the present review, we discussed, for the first time, the reported studies. The resultant data indicate that hesperidin can exert testicular protective effects through antioxidant properties.
摘要：
有毒物质主要通过激活氧化应激影响生精上皮对男性生殖系统产生不利影响。精子发生，精子,还有睾丸.有毒物质导致活性氧（ROS）的过度产生，如羟基自由基，过氧化氢,和超氧化物阴离子.ROS发挥细胞毒性作用和对核酸的氧化损伤，蛋白质，和膜脂。橙皮苷是一种药理活性植物黄酮，大量存在于柑橘类水果中，比如橘子和柠檬。它已显示出各种药理特性，如抗氧化剂，抗炎,抗癌，镇痛药,抗病毒，抗凝剂,降血脂,和降血糖作用。已发现橙皮苷对天然和化学毒素诱导的器官毒性具有保护作用。大量证据表明橙皮苷对药物以及生物和化学试剂的毒理学特性具有睾丸保护作用，在本次审查中，我们讨论过,第一次,报告的研究。所得数据表明橙皮苷可以通过抗氧化特性发挥睾丸保护作用。
