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Abstract：
Sleep is crucial for human health, insufficient sleep or poor sleep quality may negatively affect sleep function and lead to a state of sleep deprivation. Sleep deprivation can result in various health problems, including chronic pain. The intricate relationship between sleep and pain is complex and intertwined, with daytime pain affecting sleep quality and poor sleep increasing pain intensity. The article first describes the influence of sleep on the onset and development of pain, and then explores the impact of daytime pain intensity on nighttime sleep quality and subsequent pain thresholds. However, the primary emphasis is placed on the pivotal role of oxidative stress in this bidirectional relationship. Although the exact mechanisms underlying sleep and chronic pain are unclear, this review focuses on the role of oxidative stress. Numerous studies on sleep deprivation have demonstrated that it can lead to varying degrees of increased pain sensitivity, while chronic pain leads to sleep deprivation and further exacerbates pain. Further research on the role of oxidative stress in the mechanism of sleep deprivation-induced pain sensitization seems reasonable. This article comprehensively reviews the current research on the interrelationship between sleep deprivation, pain and the crucial role of oxidative stress.
摘要：
睡眠对人类健康至关重要，睡眠不足或睡眠质量差可能会对睡眠功能产生负面影响，并导致睡眠剥夺状态。睡眠不足会导致各种健康问题，包括慢性疼痛。睡眠和疼痛之间错综复杂的关系错综复杂，白天疼痛影响睡眠质量，睡眠不良增加疼痛强度。文章首先介绍了睡眠对疼痛发生和发展的影响,然后探讨了白天疼痛强度对夜间睡眠质量和随后的疼痛阈值的影响。然而,主要重点放在氧化应激在这种双向关系中的关键作用上。尽管睡眠和慢性疼痛的确切机制尚不清楚，本文对氧化应激的作用进行综述。大量关于睡眠剥夺的研究表明，它可以导致不同程度的疼痛敏感性增加，而慢性疼痛导致睡眠不足并进一步加剧疼痛。进一步研究氧化应激在睡眠剥夺引起的疼痛敏化机制中的作用似乎是合理的。本文全面回顾了当前关于睡眠剥夺之间相互关系的研究，疼痛和氧化应激的关键作用。
