PDF(Pubmed)
Abstract：
Recurrent pregnancy Loss (RPL)is a frequent and upsetting condition. Besides the prevalent cause of RPL including chromosomal defects in the embryo,the effect of translational elements like alterations of epigenetics are of great importance. The emergence of epigenetics has offered a fresh outlook on the causes and treatment of RPL by focusing on the examination of DNA methylation. RPL may arise as a result of aberrant DNA methylation of imprinted genes, placenta-specific genes, immune-related genes, and sperm DNA, which may have a direct or indirect impact on embryo implantation, growth, and development. Moreover, the distinct immunological tolerogenic milieu established at the interface between the mother and fetus plays a crucial role in sustaining pregnancy. Given this, there has been a great deal of interest in the regulation of DNA methylation and alterations in the cellular components of the maternal-fetal immunological milieu. The research on DNA methylation\'s role in RPL incidence and the control of the mother-fetal immunological milieu is summed up in this review.
摘要：
复发性妊娠丢失（RPL）是一种常见且令人沮丧的疾病。除了RPL的普遍原因，包括胚胎中的染色体缺陷，翻译元素的影响，如表观遗传学的改变是非常重要的。表观遗传学的出现通过集中于DNA甲基化的检查为RPL的原因和治疗提供了新的前景。RPL可能是由于印迹基因的异常DNA甲基化而产生的，胎盘特异性基因，免疫相关基因，和精子DNA,这可能会对胚胎植入产生直接或间接的影响，增长,和发展。此外，在母亲和胎儿之间的界面上建立的独特的免疫耐受环境在维持妊娠中起着至关重要的作用。鉴于此,DNA甲基化的调节和母胎免疫环境的细胞成分的改变引起了极大的兴趣。本文综述了DNA甲基化在RPL发病和母胎免疫环境控制中的作用。
