PDF(Pubmed)
Abstract：
This study aims to investigate the clinical course and factors associated with hospital admission and mortality among SARS-CoV-2 patients within the Nairobi Metropolitan Area. The study utilizes a multicenter retrospective cohort design, collecting clinical characteristics and laboratory parameters of hospitalized patients from March 2020 to May 2022. Data analysis includes percentages, frequencies, chi-square tests, Kaplan-Meier analysis, pairwise comparisons, and multivariate regression models. Ethical considerations are observed throughout the research process. The study findings highlight significant associations between comorbidities, such as hypertension, and increased mortality risk due to COVID-19. Symptoms including fever, cough, dyspnea, chest pain, sore throat, and loss of smell/taste are also identified as predictors of mortality. Abnormal laboratory parameters, such as oxygen saturation, procalcitonin, glucose levels, serum creatinine, and gamma-glutamyl transpeptidase, are associated with mortality. However, demographic factors and certain vital signs do not exhibit significant associations. Recommendations based on this study suggest increased monitoring and management of comorbidities, early identification and management of symptoms, regular monitoring of laboratory parameters, continued research and collaboration, and implementation of preventive measures. Overall, a multidisciplinary approach involving healthcare professionals, researchers, policymakers, and the public is crucial to improve COVID-19 outcomes and reduce mortality rates. Adaptation of strategies based on emerging evidence and resource allocation is essential for effective management of the pandemic.
摘要：
本研究旨在调查内罗毕都会区SARS-CoV-2患者的临床病程和与入院和死亡率相关的因素。本研究采用多中心回顾性队列设计，收集2020年3月至2022年5月住院患者的临床特征和实验室参数。数据分析包括百分比，频率,卡方检验,Kaplan-Meier分析,成对比较,和多元回归模型。在整个研究过程中观察到道德考虑。研究结果强调了合并症之间的显着关联，比如高血压，和COVID-19导致的死亡风险增加。症状包括发烧，咳嗽,呼吸困难,胸痛,喉咙痛,和嗅觉/味觉的丧失也被确定为死亡率的预测因子。实验室参数异常,比如氧饱和度，降钙素原,葡萄糖水平，血清肌酐,和γ-谷氨酰转肽酶,与死亡率有关。然而,人口统计学因素和某些生命体征没有显著关联.基于这项研究的建议建议加强对合并症的监测和管理，早期识别和治疗症状，定期监测实验室参数，继续研究和合作，并实施预防措施。总的来说,涉及医疗保健专业人员的多学科方法，研究人员,政策制定者，公众对改善COVID-19结局和降低死亡率至关重要。根据新出现的证据和资源分配调整战略对于有效管理大流行至关重要。
